This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
Metformin
catalog :
ALX-270-432-G005
quantity :
5 g
citations: 10
Reference
Gündüz D, Klewer M, Bauer P, Tanislav C, Sedding D, Rohrbach S, et al. Compound C inhibits in vitro angiogenesis and ameliorates thrombin-induced endothelial barrier failure. Eur J Pharmacol. 2015;768:165-72 pubmed publisher
Yokokawa T, Sato K, Iwanaka N, Honda H, Higashida K, Iemitsu M, et al. Dehydroepiandrosterone activates AMP kinase and regulates GLUT4 and PGC-1α expression in C2C12 myotubes. Biochem Biophys Res Commun. 2015;463:42-7 pubmed publisher
Tang Q, Zhao S, Wu J, Zheng F, Yang L, Hu J, et al. Inhibition of integrin-linked kinase expression by emodin through crosstalk of AMPKα and ERK1/2 signaling and reciprocal interplay of Sp1 and c-Jun. Cell Signal. 2015;27:1469-77 pubmed publisher
Ishikawa K, Tsunekawa S, Ikeniwa M, Izumoto T, Iida A, Ogata H, et al. Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. PLoS ONE. 2015;10:e0115350 pubmed publisher
Feng Y, Velazquez Torres G, Gully C, Chen J, Lee M, Yeung S. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med. 2011;15:825-36 pubmed publisher
Caton P, Nayuni N, Kieswich J, Khan N, Yaqoob M, Corder R. Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5. J Endocrinol. 2010;205:97-106 pubmed publisher
Towler M, Hardie D. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res. 2007;100:328-41 pubmed
Zakikhani M, Dowling R, Fantus I, Sonenberg N, Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 2006;66:10269-73 pubmed
Misugi T, Ozaki K, El Beltagy K, Tokuyama O, Honda K, Ishiko O. Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats. Gynecol Obstet Invest. 2006;61:208-15 pubmed
Natali A, Ferrannini E. Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review. Diabetologia. 2006;49:434-41 pubmed
product information
Product ID :
ALX-270-432
Catalog Number :
ALX-270-432-G005
Product Name :
Metformin
Product Type :
Biochemical
Size :
5 g
list of Pubmed id :
26522925, 25983323, 25889897, 25658116, 20455996, 20093281, 17307971, 17062558, 16479139, 16477438
Product Description :
Metformin is an antidiabetic agent. Reduces the cardiovascular complications of diabetes. Does not induce hypoglycemia. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Has antiproliferative effects in cancer cell lines.
ALTnames :
1,1-Dimethylbiguanide . hydrochloride
Purity :
≥97% (Assay)
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.