DAPT | Enzo Life Sciences ALX-270-416-M025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

DAPT

catalog :

ALX-270-416-M025

quantity :

25 mg

citations: 8

Reference
Oswald F, Rodriguez P, Giaimo B, Antonello Z, Mira L, Mittler G, et al. A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes. Nucleic Acids Res. 2016;44:4703-20 pubmed publisher
Hartmann M, Parra L, Ruschel A, Lindner C, Morrison H, Herrlich A, et al. Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization. J Biol Chem. 2015;290:17041-54 pubmed publisher
Sörensen I, Adams R, Gossler A. DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 2009;113:5680-8 pubmed publisher
Gowrishankar K, Zeidler M, Vincenz C. Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD. J Cell Sci. 2004;117:4099-111 pubmed
Campbell W, Reed M, Strahle J, Wolfe M, Xia W. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. J Neurochem. 2003;85:1563-74 pubmed
Lanz T, Himes C, Pallante G, Adams L, Yamazaki S, Amore B, et al. The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice. J Pharmacol Exp Ther. 2003;305:864-71 pubmed
Geling A, Steiner H, Willem M, Bally Cuif L, Haass C. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep. 2002;3:688-94 pubmed
Dovey H, John V, Anderson J, Chen L, de Saint Andrieu P, Fang L, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001;76:173-81 pubmed

product information

Product ID :

ALX-270-416

Catalog Number :

ALX-270-416-M025

Product Name :

DAPT

Product Type :

Biochemical

Size :

25 mg

list of Pubmed id :

25925953, 19144989, 15280425, 12787075, 12626636, 12101103, 11145990

Product Description :

Cell permeable inhibitor of γ-secretase (IC50=115nM for total β-amyloid, IC50=200nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD)Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.

ALTnames :

N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester, γ-Secretase inhibitor IX

Purity :

≥98% (HPLC)

Storage :

-20°C