Indirubin | Enzo Life Sciences ALX-270-361-M001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Indirubin

catalog :

ALX-270-361-M001

quantity :

1 mg

citations: 6

Reference
Sethi G, Ahn K, Sandur S, Lin X, Chaturvedi M, Aggarwal B. Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem. 2006;281:23425-35 pubmed
Eisenbrand G, Hippe F, Jakobs S, Muehlbeyer S. Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine. J Cancer Res Clin Oncol. 2004;130:627-35 pubmed
Adachi J, Mori Y, Matsui S, Takigami H, Fujino J, Kitagawa H, et al. Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. J Biol Chem. 2001;276:31475-8 pubmed
Kunikata T, Tatefuji T, Aga H, Iwaki K, Ikeda M, Kurimoto M. Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity. Eur J Pharmacol. 2000;410:93-100 pubmed
Leclerc S, Garnier M, Hoessel R, Marko D, Bibb J, Snyder G, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?. J Biol Chem. 2001;276:251-60 pubmed
Hoessel R, Leclerc S, Endicott J, Nobel M, Lawrie A, Tunnah P, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999;1:60-7 pubmed

product information

Product ID :

ALX-270-361

Catalog Number :

ALX-270-361-M001

Product Name :

Indirubin

Product Type :

Biochemical

Size :

1 mg

list of Pubmed id :

16785236, 15340840, 11425848, 11134660, 11013232, 10559866

Product Description :

Inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50=10µM), CDK2/cyclin A (IC50=2.2µM), CDK2/cyclin E (IC50=7.5µM), CDK4/cyclin D1 (IC50=12µM), CDK5/p35 (IC50=5.5µM)) and of GSK-3β (IC50=600nM). Inhibits inflammatory reaction in delayed-type hypersensitivity in mice. Ligand of human aryl hydrocarbon receptor. Exhibits anti-cancer activity.

Background :

Indirubin is derived from various natural sources, such as Indigofera indica, Isatis tinctoria and I. indigotica by fermentation, oxidation and the presence of light as a by product of indigo formation. Indirubin is also present in human urine and fetal bovine serum. Preclinical studies of indirubin confirmed its anti-tumor activity. Efficacy against chronic myelocytic leukemia was demonstrated in clinical trials in China.

Purity :

≥98% (1H-NMR, HPLC)

Storage :

+4°C