This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
T0901317
catalog :
ALX-270-309-M010
quantity :
10 mg
citations: 6
Reference
Chuu C, Chen R, Hiipakka R, Kokontis J, Warner K, Xiang J, et al. The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells. Biochem Biophys Res Commun. 2007;357:341-6 pubmed
Fukuchi J, Kokontis J, Hiipakka R, Chuu C, Liao S. Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells. Cancer Res. 2004;64:7686-9 pubmed
DeBose Boyd R, Ou J, Goldstein J, Brown M. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proc Natl Acad Sci U S A. 2001;98:1477-82 pubmed
Laffitte B, Repa J, Joseph S, Wilpitz D, Kast H, Mangelsdorf D, et al. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001;98:507-12 pubmed
Schultz J, Tu H, Luk A, Repa J, Medina J, Li L, et al. Role of LXRs in control of lipogenesis. Genes Dev. 2000;14:2831-8 pubmed
Repa J, Turley S, Lobaccaro J, Medina J, Li L, Lustig K, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 2000;289:1524-9 pubmed
product information
Product ID :
ALX-270-309
Catalog Number :
ALX-270-309-M010
Product Name :
T0901317
Product Type :
Biochemical
Size :
10 mg
list of Pubmed id :
17416342, 15520170, 11171976, 11149950, 11090131, 10968783
Product Description :
Potent agonist (EC50=50nM) of the orphan nuclear hormone receptor (liver X receptor; LXR). Inhibitor of human sex hormone-dependent cancer cell lines.
ALTnames :
N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
Purity :
≥98% (HPLC)
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.