4-Hydroxyquinazoline | Enzo Life Sciences ALX-270-279-G001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

4-Hydroxyquinazoline

catalog :

ALX-270-279-G001

quantity :

1 g

citations: 4

Reference
Kleine H, Poreba E, Lesniewicz K, Hassa P, Hottiger M, Litchfield D, et al. Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. Mol Cell. 2008;32:57-69 pubmed publisher
Veres B, Radnai B, Gallyas F, Varbiro G, Berente Z, Osz E, et al. Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther. 2004;310:247-55 pubmed
Halmosi R, Berente Z, Osz E, Toth K, Literati Nagy P, Sumegi B. Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Mol Pharmacol. 2001;59:1497-505 pubmed
Banasik M, Komura H, Shimoyama M, Ueda K. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J Biol Chem. 1992;267:1569-75 pubmed

product information

Product ID :

ALX-270-279

Catalog Number :

ALX-270-279-G001

Product Name :

4-Hydroxyquinazoline

Product Type :

Biochemical

Size :

1 g

list of Pubmed id :

18851833, 14999056, 11353811, 1530940

Product Description :

Potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) (IC50=9.5μM). Attenuates activation of ERK and p38 MAP kinase induced by LPS. Displays beneficial effects in LPS-induced endotoxic shock. Protects the heart from oxidative damage during reperfusion injury.

ALTnames :

4-HQN, 4-Quinazolinol

Purity :

≥98% (HPLC)

Storage :

+4°C