Purvalanol A | Enzo Life Sciences ALX-270-246-M005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Purvalanol A

catalog :

ALX-270-246-M005

quantity :

5 mg

citations: 4

Reference
Lawrence E, Mandato C. Mitochondria localize to the cleavage furrow in mammalian cytokinesis. PLoS ONE. 2013;8:e72886 pubmed publisher
Monaco E, Beaman Hall C, Mathur A, Vallano M. Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons. Biochem Pharmacol. 2004;67:1947-64 pubmed
Chadebech P, Truchet I, Brichese L, Valette A. Up-regulation of cdc2 protein during paclitaxel-induced apoptosis. Int J Cancer. 2000;87:779-86 pubmed
Gray N, Wodicka L, Thunnissen A, Norman T, Kwon S, Espinoza F, et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998;281:533-8 pubmed

product information

Product ID :

ALX-270-246

Catalog Number :

ALX-270-246-M005

Product Name :

Purvalanol A

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

23991162, 15130771, 10956385, 9677190

Product Description :

Inhibitor of human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well as CDK5/p35 (IC50=75nM). More membrane permeable than purvalanol B.

ALTnames :

6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine

Purity :

≥99% (NMR)

Storage :

-20°C