(E)-4-Hydroxynonenal | Enzo Life Sciences ALX-270-245-M005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

(E)-4-Hydroxynonenal

catalog :

ALX-270-245-M005

quantity :

5 mg

citations: 10

Reference
Gargiulo S, Gamba P, Testa G, Rossin D, Biasi F, Poli G, et al. Relation between TLR4/NF-ÎºB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability. Aging Cell. 2015;14:569-81 pubmed publisher
Poole D, Pelayo J, Cattaruzza F, Kuo Y, Gai G, Chiu J, et al. Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine. Gastroenterology. 2011;141:565-75, 575.e1-4 pubmed publisher
Ji C, Kozak K, Marnett L. IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem. 2001;276:18223-8 pubmed
Camandola S, Poli G, Mattson M. The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons. Brain Res Mol Brain Res. 2000;85:53-60 pubmed
Renes J, de Vries E, Hooiveld G, Krikken I, Jansen P, Muller M. Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation product 4-hydroxynonenal. Biochem J. 2000;350 Pt 2:555-61 pubmed
Neely M, Sidell K, Graham D, Montine T. The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin. J Neurochem. 1999;72:2323-33 pubmed
Page S, Fischer C, Baumgartner B, Haas M, Kreusel U, Loidl G, et al. 4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis. J Biol Chem. 1999;274:11611-8 pubmed
Morel P, Tallineau C, Pontcharraud R, Piriou A, Huguet F. Effects of 4-hydroxynonenal, a lipid peroxidation product, on dopamine transport and Na+/K+ ATPase in rat striatal synaptosomes. Neurochem Int. 1998;33:531-40 pubmed
Markesbery W, Carney J. Oxidative alterations in Alzheimer's disease. Brain Pathol. 1999;9:133-46 pubmed
Pedersen W, Cashman N, Mattson M. The lipid peroxidation product 4-hydroxynonenal impairs glutamate and glucose transport and choline acetyltransferase activity in NSC-19 motor neuron cells. Exp Neurol. 1999;155:1-10 pubmed

product information

Product ID :

ALX-270-245

Catalog Number :

ALX-270-245-M005

Product Name :

(E)-4-Hydroxynonenal

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

25757594, 21689654, 11359792, 11146106, 10947971, 10349841, 10206970, 10098723, 9989456, 9918699

Product Description :

Among the aldehydes formed, 4-HNE is the major product of lipid peroxidation, and it has been suggested to play a major role in liver toxicity associated with lipid peroxidation. Prevents NF-κB activation and TNF expression by inhibiting IκB phosphorylation and subsequent proteolysis.

ALTnames :

4-HNE

Purity :

≥90% (HPLC) (precursor dimethylacetal)

Buffer :

Liquid. Solution in n-hexane.

Storage :

-80°C