This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
chemical
product name :
AM 281
catalog :
ALX-270-240-M005
quantity :
5 mg
citations: 6
Reference
Kadoi Y, Hinohara H, Kunimoto F, Saito S, Goto F. Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats. Crit Care Med. 2005;33:2629-36 pubmed
Kadoi Y, Hinohara H, Kunimoto F, Kuwano H, Saito S, Goto F. Effects of AM281, a cannabinoid antagonist, on systemic haemodynamics, internal carotid artery blood flow and mortality in septic shock in rats. Br J Anaesth. 2005;94:563-8 pubmed
Werner N, Koch J. Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats. Brain Res. 2003;967:290-2 pubmed
Gifford A, Bruneus M, Gatley S, Lan R, Makriyannis A, Volkow N. Large receptor reserve for cannabinoid actions in the central nervous system. J Pharmacol Exp Ther. 1999;288:478-83 pubmed
Gifford A, Tang Y, Gatley S, Volkow N, Lan R, Makriyannis A. Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices. Neurosci Lett. 1997;238:84-6 pubmed
Gatley S, Lan R, Volkow N, Pappas N, King P, Wong C, et al. Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo. J Neurochem. 1998;70:417-23 pubmed
product information
Product ID :
ALX-270-240
Catalog Number :
ALX-270-240-M005
Product Name :
AM 281
Product Type :
Biochemical
Size :
5 mg
list of Pubmed id :
16276190, 15734782, 12650991, 9918548, 9464661, 9422389
Product Description :
Analog of the cannabinoid receptor (CB) antagonist SR 141716A. Potent CB1 receptor antagonist/inverse agonist (Ki=14nM).
ALTnames :
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
Purity :
≥98% (HPLC)
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.