Piceatannol | Enzo Life Sciences ALX-270-202-M005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Piceatannol

catalog :

ALX-270-202-M005

quantity :

5 mg

citations: 10

Reference
Chiou E, Zennadi R. GÎ±s proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-Î±vÎ²3 and CD44-CD44 interactions. Int J Biochem Cell Biol. 2015;65:40-51 pubmed publisher
Howitz K, Bitterman K, Cohen H, Lamming D, Lavu S, Wood J, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425:191-6 pubmed
Seow C, Chue S, Wong W. Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro. Eur J Pharmacol. 2002;443:189-96 pubmed
Cambien B, Millet M, Schmid Antomarchi H, Brossette N, Rossi B, Schmid Alliana A. Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells. J Immunol. 1999;163:5079-85 pubmed
Tkaczyk C, Villa I, Peronet R, David B, Mecheri S. FcepsilonRI-mediated antigen endocytosis turns interferon-gamma-treated mouse mast cells from inefficient into potent antigen-presenting cells. Immunology. 1999;97:333-40 pubmed
Zheng J, Ramirez V. Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complex. Biochem Biophys Res Commun. 1999;261:499-503 pubmed
Muller J, Davis M, Chilian W. Coronary arteriolar flow-induced vasodilation signals through tyrosine kinase. Am J Physiol. 1996;270:H1878-84 pubmed
Peters J, Furlong M, Asai D, Harrison M, Geahlen R. Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J Biol Chem. 1996;271:4755-62 pubmed
Oliver J, Burg D, Wilson B, McLaughlin J, Geahlen R. Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J Biol Chem. 1994;269:29697-703 pubmed
Fleming I, Fisslthaler B, Busse R. Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases. Circ Res. 1995;76:522-9 pubmed

product information

Product ID :

ALX-270-202

Catalog Number :

ALX-270-202-M005

Product Name :

Piceatannol

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

26007235, 12939617, 12044809, 10528214, 10447750, 10425214, 8764235, 8617742, 7961959, 7895328

Product Description :

Originally isolated from Euphorbia lagascae. Selective protein tyrosine kinase Syk inhibitor (IC50~10 µM). In RBL-2H3 cells the selective inhibition of Syk by piceatannol results in inhibition of FcεR1-mediated signaling. Activator of human deacetylase SIRT1.

ALTnames :

3,4,3',5'-Tetrahydroxy-trans-stilbene

Purity :

≥98% (HPLC (UV))

Storage :

+4°C