Indomethacin | Enzo Life Sciences ALX-270-086-G005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Indomethacin

catalog :

ALX-270-086-G005

quantity :

5 g

citations: 6

Reference
Lehmann J, Lenhard J, Oliver B, Ringold G, Kliewer S. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1997;272:3406-10 pubmed
Meade E, Smith W, DeWitt D. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1993;268:6610-4 pubmed
Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994;47:55-9 pubmed
Salari H, Braquet P, Borgeat P. Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets. Prostaglandins Leukot Med. 1984;13:53-60 pubmed
Stevenson K, Lumbers E. Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production. J Dev Physiol. 1992;17:257-64 pubmed
Shen T, Winter C. Chemical and biological studies on indomethacin, sulindac and their analogs. Adv Drug Res. 1977;12:90-245 pubmed

product information

Product ID :

ALX-270-086

Catalog Number :

ALX-270-086-G005

Product Name :

Indomethacin

Product Type :

Biochemical

Size :

5 g

list of Pubmed id :

9013583, 8454631, 8140262, 6424136, 1289388, 343530

Product Description :

Non-steroidal anti-inflammatory and analgesic agent. Inhibits cyclooxygenase (IC50=0.1µM) selectively over lipoxygenases (IC50=100µM for 5-, 12- and 15-LO). Preferentially inhibits PGH synthase-1 over PGH synthase-2 (ID50=4.9-8.1 and 130-160µM respectively). Activates PPARα and γ receptors and induces adipocyte differentiation (EC50=8µM). A clinically useful NSAID.

Purity :

≥98% (HPLC)

Storage :

Ambient