Actinonin | Enzo Life Sciences ALX-260-128-M005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

chemical

product name :

Actinonin

catalog :

ALX-260-128-M005

quantity :

5 mg

citations: 9

Reference
Grujic M, Zavasnik Bergant T, Pejler G, Renko M. Actinonin induces apoptosis in U937 leukemia cells. Cancer Lett. 2005;223:211-8 pubmed
Lee M, She Y, Soskis M, Borella C, Gardner J, Hayes P, et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest. 2004;114:1107-16 pubmed
Chen D, Patel D, Hackbarth C, Wang W, Dreyer G, Young D, et al. Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry. 2000;39:1256-62 pubmed
Lendeckel U, Kahne T, Arndt M, Frank K, Ansorge S. Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299. Biochem Biophys Res Commun. 1998;252:5-9 pubmed
Xu Y, Lai L, Gabrilove J, Scheinberg D. Antitumor activity of actinonin in vitro and in vivo. Clin Cancer Res. 1998;4:171-6 pubmed
Ho T, Qoronfleh M, Wahl R, Pulvino T, Vavra K, Falvo J, et al. Gene expression, purification and characterization of recombinant human neutrophil collagenase. Gene. 1994;146:297-301 pubmed
Sayama K, Goto Y, Iguchi T, Takeda Y, Matsuzawa A. Effects of an antibiotic protease inhibitor, actinonin on the growth within collagen gels of non-metastatic and metastatic mouse mammary tumors of the same origin. Cancer Lett. 1995;94:171-7 pubmed
Hachisu M, Hiranuma T, Murata S, Aoyagi T, Umezawa H. Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes. Life Sci. 1987;41:235-40 pubmed
Umezawa H, Aoyagi T, Tanaka T, Suda H, Okuyama A, Naganawa H, et al. Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes. J Antibiot (Tokyo). 1985;38:1629-30 pubmed

product information

Product ID :

ALX-260-128

Catalog Number :

ALX-260-128-M005

Product Name :

Actinonin

Product Type :

Biochemical

Size :

5 mg

list of Pubmed id :

15896455, 15489958, 10684604, 9813136, 9516967, 8076835, 7634245, 3298909, 2867082

Product Description :

Antibiotic. Inhibitor of aminopeptidase M, N and leucine and alanyl aminopeptidase and peptide deformylase (PDF). Inhibits MMP-1 (Ki=300nM), MMP-2 (IC50~90nM at MMP-2=5nM), MMP-3 (Ki=1’700nM), MMP-7 (IC50~3’500nM at MMP-7=19nM), MMP-8 (Ki=160nM), MMP-9 (Ki=330nM), MMP-10 (IC50~500nM at MMP-10=22nM), MMP-12 (IC50~350nM at MMP-12=4nM), and MMP-13 (IC50~100nM at MMP-13=13nM), but not MMP-14 (IC50>1mM at MMP-14=13.6nM). Shows antitumor activity in vitro and in vivo. Apoptosis inducer.

ALTnames :

3[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]-carbonyl]-2-methylpropyl]-carbamoyl]-octanohydroxamic acid

Purity :

≥98% (HPLC)

Storage :

-20°C