This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
protein
product name :
γ-Secretase inhibitor
catalog :
ALX-260-127-M001
quantity :
1 mg
citations: 7
Reference
Huenniger K, Kramer A, Soom M, Chang I, Kohler M, Depping R, et al. Notch1 signaling is mediated by importins alpha 3, 4, and 7. Cell Mol Life Sci. 2010;67:3187-96 pubmed publisher
Sörensen I, Adams R, Gossler A. DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 2009;113:5680-8 pubmed publisher
Campbell W, Reed M, Strahle J, Wolfe M, Xia W. Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. J Neurochem. 2003;85:1563-74 pubmed
Meyer E, Strutz N, Gahring L, Rogers S. Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase. J Biol Chem. 2003;278:23786-96 pubmed
Wolfe M, Xia W, Moore C, Leatherwood D, Ostaszewski B, Rahmati T, et al. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry. 1999;38:4720-7 pubmed
Wolfe M, Citron M, Diehl T, Xia W, Donkor I, Selkoe D. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. J Med Chem. 1998;41:6-9 pubmed
Citron M, Diehl T, Gordon G, Biere A, Seubert P, Selkoe D. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc Natl Acad Sci U S A. 1996;93:13170-5 pubmed
product information
Product ID :
ALX-260-127
Catalog Number :
ALX-260-127-M001
Product Name :
γ-Secretase inhibitor
Product Type :
Peptide
Size :
1 mg
list of Pubmed id :
20454918, 19144989, 12787075, 12700243, 10200159, 9438016, 8917563
Product Description :
Reversible peptidomimetic inhibitor of γ-secretase (IC50=10-25µM for total β-amyloid), presenilinase (IC50=0.1-1µM), and calpain II (IC50=100µM).
ALTnames :
MW167
Purity :
≥90%
Buffer :
Lyophilized
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.