This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
protein
product name :
Furin convertase inhibitor (chloromethylketone)
catalog :
ALX-260-022-M001
quantity :
1 mg
citations: 10
Reference
Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, et al. PCSK6-mediated corin activation is essential for normal blood pressure. Nat Med. 2015;21:1048-53 pubmed publisher
Kang H, Duran C, Abbey C, Kaunas R, Bayless K. Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP. Biochem Biophys Res Commun. 2015;460:596-602 pubmed publisher
Fu J, Bassi D, Zhang J, Li T, Cai K, Testa C, et al. Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases. Neoplasia. 2013;15:169-79 pubmed
Ennemann E, Radhakrishnan K, Mariappan M, Wachs M, Pringle T, Schmidt B, et al. Proprotein convertases process and thereby inactivate formylglycine-generating enzyme. J Biol Chem. 2013;288:5828-39 pubmed publisher
Butterworth M, Zhang L, Heidrich E, MYERBURG M, Thibodeau P. Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa. J Biol Chem. 2012;287:32556-65 pubmed
Von Marschall Z, Fisher L. Decorin is processed by three isoforms of bone morphogenetic protein-1 (BMP1). Biochem Biophys Res Commun. 2010;391:1374-8 pubmed publisher
Kaup M, Dassler K, Weise C, Fuchs H. Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor alpha protease inhibitor-2. J Biol Chem. 2002;277:38494-502 pubmed
Fugere M, Limperis P, Beaulieu Audy V, Gagnon F, Lavigne P, Klarskov K, et al. Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains. J Biol Chem. 2002;277:7648-56 pubmed
Sato T, Kondo T, Fujisawa T, Seiki M, Ito A. Furin-independent pathway of membrane type 1-matrix metalloproteinase activation in rabbit dermal fibroblasts. J Biol Chem. 1999;274:37280-4 pubmed
Deb S, Zhang J, Gottschall P. Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide. J Neurosci Res. 1999;55:44-53 pubmed
product information
Product ID :
ALX-260-022
Catalog Number :
ALX-260-022-M001
Product Name :
Furin convertase inhibitor (chloromethylketone)
Product Type :
Peptide
Size :
1 mg
list of Pubmed id :
26259032, 25800869, 23441131, 23288839, 22859302, 20026052, 12163483, 11723118, 10601293, 9890433
Product Description :
Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases: furin/SPC1 (Ki~1nM), SPC2/PC2 (Ki=0.36nM), SPC3/PC1/PC3(Ki=2.0nM), SPC4/PACE4 (Ki=3.6nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki=0.12nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in various cell lines, including U87 and HT1080 cells. Typical concentration range used in tissue culture is 25-100µM.
ALTnames :
Decanoyl-Arg-Val-Lys-Arg-chloromethylketone, Dec-RVKR-CMK, TACE inhibitor
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.