product summary
Loading...
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
[pSer282]Myosin-binding protein C (cardiac type) polyclonal antibody
catalog :
ALX-215-057-R050
quantity :
50 µl
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat, dogs
application :
western blot, immunocytochemistry
more info or order :
Enzo Life Sciences product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000; loading ...; fig 1c
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamás K, Hadgraft N, Martin E, et al. Disulfide-activated protein kinase G I? regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response. Nat Commun. 2016;7:13187 pubmed publisher
product information
Product ID :
ALX-215-057
Catalog Number :
ALX-215-057-R050
Product Name :
[pSer282]Myosin-binding protein C (cardiac type) polyclonal antibody
Host species :
Rabbit
Clonality :
Polyclonal
Antigen modification :
Phosphorylated
Product Type :
Antibody
Size :
50 µl
list of Pubmed id :
26346517, 16894034
SPECIES REACTIVITY :
Human, Mouse, Rat, Dog
Background :
Myosin-binding protein 2 (cardiac type) (cMyBP-C) is a protein located in the C-zones of the A-band of the sarcomere and interacts specifically with myosin, titin and actin. Mutations in the human cMyBP-C gene are one of the most frequent causes of familial hypertrophic cardiomyopathy. cMyBP-C can be phosphorylated at three different sites by a cAMP-regulated protein kinase (PKA) and a Ca2+<-calmodulin kinase (CAMK) bound to the thick filament. The dephosphorylated form binds to the S2 subfragment of myosin whereas the phosphorylated form binds to actin. In solution, phosphorylation of cMyBP-C increases force of contraction, but both phospho- and dephosphorylated forms of cMyBP-C stimulate the actin-activated myosin ATPase activity.
ALTnames :
cMyBP-C, MYBPC3
Immunogen :
Synthetic peptide corresponding to aa 276-288 (G276AGRRTpSDSHEDA288) of myosin-binding protein 2 (cardiac type) (cMyBP-C) phosphorylated at Ser282.
Specificity :
Recognizes cMyBP-C phosphorylated at Ser282.
Buffer :
Liquid. In phosphate buffer, pH 7.4, containing 0.1% BSA and 0.01% thimerosal.
Uses :
Detects a band of ~150kDa by Western blot.
Application Summary :
ICC, WB
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.