Cyclophilin A (human) polyclonal antibody | Enzo Life Sciences ALX-210-351-R400 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Cyclophilin A (human) polyclonal antibody

catalog :

ALX-210-351-R400

quantity :

400 µl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

citations: 1

Reference
Yoshikawa R, Izumi T, Nakano Y, Yamada E, Moriwaki M, Misawa N, et al. Small ruminant lentiviral Vif proteins commonly utilize cyclophilin A, an evolutionarily and structurally conserved protein, to degrade ovine and caprine APOBEC3 proteins. Microbiol Immunol. 2016;60:427-36 pubmed publisher

product information

Product ID :

ALX-210-351

Catalog Number :

ALX-210-351-R400

Product Name :

Cyclophilin A (human) polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

400 µl

SPECIES REACTIVITY :

Human, Hamster

Background :

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signalling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.

ALTnames :

CyPA, Peptidyl-prolyl cis-trans isomerase A

Immunogen :

Recombinant human cyclophilin A.

Specificity :

Recognizes overexpressed human cyclophilin A. Does not detect endogenous levels of cyclophilin A. Also detects hamster cyclophilin A in CHO cells.

Buffer :

Liquid. In PBS containing 0.05% sodium azide.

Uses :

Detects a prominent band of ~18kDa representing recombinant human cyclophilin A by Western blot. Does not detect endogenous levels of cyclophilin A. Also detects hamster cyclophilin A in CHO cells.

Application Summary :

Storage :

-20°C