SNAP-25 polyclonal antibody | Enzo Life Sciences ALX-210-279-R100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

SNAP-25 polyclonal antibody

catalog :

ALX-210-279-R100

quantity :

100 µl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat, bovine, zebrafish

application :

western blot, immunocytochemistry

product information

Product ID :

ALX-210-279

Catalog Number :

ALX-210-279-R100

Product Name :

SNAP-25 polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

100 µl

SPECIES REACTIVITY :

Mouse, Rat, Zebrafish, Bovine

Background :

SNAP-25 (synaptosomal associated protein of 25kDa) is a soluble protein of 25kDa which plays a key role in vesicle membrane fusion events with the plasma membrane. This protein was originally discovered to be enriched in subsets of neurons in the brain and displays a presynaptic pattern of expression. The membrane proteins SNAP-25, synaptobrevin, and syntaxin form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins NSF and α-SNAP. Functional interactions have been demonstrated to exist between SNAP-25, syntaxin, and the synaptic protein interaction site on voltage-sensitive L- and N-type Ca2+ channels. SNAP-25 has been shown to be required for synaptic vesicle fusion with the plasma membrane during release of NGF. Regulated exocytosis of cortical granule secretion in fertilized eggs and membrane fusion events in neurons and endocrine cells is mediated by SNAP-25 in a Ca2+-dependent mechanism. SNAP-25 protein levels have been shown to be elevated in prolactinoma and GH/PRL tumor cells while reduced SNAP-25 protein expression has been observed between schizophrenic and normal hippocampal cells. Altered patterns of SNAP-25 expression have also been observed in the inferior temporal cortex and prefrontal association cortex between normal brains and brains from individuals affected with schizophrenia. SNAP-25 accumulation due to cytoskeletal dysfunction is also observed in the swollen axons of the white matter of individuals with severe Alzheimer's dementia.

ALTnames :

Synaptosomal-associated protein 25

Immunogen :

Synthetic peptide corresponding to aa 195-206 (A195NQRATKML. GSG206) of rat SNAP-25 (synaptosomal-associated protein 25).

Buffer :

Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.

Uses :

Detects a band of ~25kDa by Western blot.

Application Summary :

ICC, WB

Storage :

-20°C