Control:Fc fusion protein (human), (recombinant) | Enzo Life Sciences ALX-203-004-C050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

Control:Fc fusion protein (human), (recombinant)

catalog :

ALX-203-004-C050

quantity :

50 µg

citations: 3

Reference
FilkovÃ¡ M, VernerovÃ¡ Z, HulejovÃ¡ H, PrajzlerovÃ¡ K, Veigl D, Pavelka K, et al. Pro-inflammatory effects of interleukin-35 in rheumatoid arthritis. Cytokine. 2015;73:36-43 pubmed publisher
Keiper T, Al Fakhri N, Chavakis E, Athanasopoulos A, Isermann B, Herzog S, et al. The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment. FASEB J. 2005;19:2078-80 pubmed
Silva Santos B, Pennington D, Hayday A. Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors. Science. 2005;307:925-8 pubmed

product information

Product ID :

ALX-203-004

Catalog Number :

ALX-203-004-C050

Product Name :

Control:Fc fusion protein (human), (recombinant)

Product Type :

Protein

Size :

50 µg

list of Pubmed id :

25697137, 16195363, 15591166

Product Description :

Negative control for Fc chimeric proteins. Does not bind to a series of ligands in an ELISA assay. Does not inhibit binding between the thymoma cell line EL-4 expressing β3-integrin and astrocytes expressing high level of Thy-1 in mice.

Background :

Thy-1 is a glycosyl phosphatidylinositol (GPI)- anchored glycoprotein of the immunoglobulin superfamily expressed in various cell types, particularly in T-lymphocytes and cells of the neuronal system. Thy-1 is involved in cell adhesion, and the presence of a RLD motifs, which is recognized by intengrins, strengthen the hypothesis that the Thy-1:integrin interaction is responsible for cell attachment. In astrocytes, binding of Thy-1 to β3-integrin triggers tyrosine phosphorylation of focal adhesion proteins.

ALTnames :

Thy-1 (RLE mutant)

Specificity :

Does not bind to β3-integrin nor to any of a large number of tested TNF-superfamily members including rhsTRAIL, rhsCD40L, rhsAPRIL, etc.

Purity :

≥90% (SDS-PAGE)

Buffer :

Lyophilized. Contains PBS.

Uses :

Control compound for Fc Tagged Proteins, ELISA, Flow Cytometry, Functional Application (serves as a negative control in functional assays of TNF-superfamily members).

Storage :

-20°C