Elafin (human), (recombinant) | Enzo Life Sciences ALX-201-240-C100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

Elafin (human), (recombinant)

catalog :

ALX-201-240-C100

quantity :

100 µg

citations: 10

Reference
Caruso J, Hunt K, Keyomarsi K. The neutrophil elastase inhibitor elafin triggers rb-mediated growth arrest and caspase-dependent apoptosis in breast cancer. Cancer Res. 2010;70:7125-36 pubmed publisher
Williams S, Brown T, Roghanian A, Sallenave J. SLPI and elafin: one glove, many fingers. Clin Sci (Lond). 2006;110:21-35 pubmed
Guyot N, Zani M, Maurel M, Dallet Choisy S, Moreau T. Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase. Biochemistry. 2005;44:15610-8 pubmed
Brown T, Mistry R, Collie D, Tate S, Sallenave J. Trappin ovine molecule (TOM), the ovine ortholog of elafin, is an acute phase reactant in the lung. Physiol Genomics. 2004;19:11-21 pubmed publisher
Sallenave J. The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease. Respir Res. 2000;1:87-92 pubmed
Ying Q, Simon S. Kinetics of the inhibition of proteinase 3 by elafin. Am J Respir Cell Mol Biol. 2001;24:83-89 pubmed
Schalkwijk J, Wiedow O, Hirose S. The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core. Biochem J. 1999;340 ( Pt 3):569-77 pubmed
Zeeuwen P, Hendriks W, de Jong W, Schalkwijk J. Identification and sequence analysis of two new members of the SKALP/elafin and SPAI-2 gene family. Biochemical properties of the transglutaminase substrate motif and suggestions for a new nomenclature. J Biol Chem. 1997;272:20471-8 pubmed
Tamechika I, Itakura M, Saruta Y, Furukawa M, Kato A, Tachibana S, et al. Accelerated evolution in inhibitor domains of porcine elafin family members. J Biol Chem. 1996;271:7012-8 pubmed
Sallenave J, Silva A. Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions. Am J Respir Cell Mol Biol. 1993;8:439-45 pubmed

product information

Product ID :

ALX-201-240

Catalog Number :

ALX-201-240-C100

Product Name :

Elafin (human), (recombinant)

Product Type :

Protein

Size :

100 µg

list of Pubmed id :

20823156, 16336202, 16300411, 15292488, 11667971, 11152654, 10359639, 9252357, 8636131, 8476637

Background :

Belongs to the chelonianin family of protease inhibitors and is involved in the physiological control of neutrophil serine proteinases, where it targets NE and proteinase 3. Shows antiprotease, antibacterial and antiinflammatory activity and primes innate immunity.

ALTnames :

ESI, Elastase-specific inhibitor, SKALP, Skin-derived antileukoproteinase, Protease inhibitor WAP3

Purity :

≥90% (HPLC, SDS-PAGE, MS)

Buffer :

Lyophilized

Storage :

-20°C