Caspase-1 (human), (recombinant) (active) | Enzo Life Sciences ALX-201-056-U100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

Caspase-1 (human), (recombinant) (active)

catalog :

ALX-201-056-U100

quantity :

100 U

citations: 2

Reference
Talabot Ayer D, Lamacchia C, Gabay C, Palmer G. Interleukin-33 is biologically active independently of caspase-1 cleavage. J Biol Chem. 2009;284:19420-6 pubmed publisher
Buck M, Poli V, Hunter T, Chojkier M. C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol Cell. 2001;8:807-16 pubmed

product information

Product ID :

ALX-201-056

Catalog Number :

ALX-201-056-U100

Product Name :

Caspase-1 (human), (recombinant) (active)

Product Type :

Protein

Size :

100 U

list of Pubmed id :

19465481, 11684016

Background :

Caspase-1 is the prototypical member of the caspase family of cysteine proteases. Caspase-1 exists in cells as an inactive 45kDa pro-enzyme. The pro-enzyme is matured by proteolysis to yield large (20kDa) and small (10kDa) subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of regulation of caspase-1 activation is complex and poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive pro-enzyme form.

ALTnames :

Interleukin 1β converting enzyme, IL-1β converting enzyme, ICE

Buffer :

Lyophilized

Uses :

Useful in studying enzyme regulation and inhibitors, determining target substrate, screening caspase inhibitors, or as a positive control in caspase assays. We recommend using 1 unit per assay for analyzing caspase activity.

Storage :

-80°C