Caspase-9 (human), (recombinant) (active) | Enzo Life Sciences ALX-201-047-U100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

Caspase-9 (human), (recombinant) (active)

catalog :

ALX-201-047-U100

quantity :

100 U

citations: 6

Reference
McMillan E, Quadrilatero J. Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles. Am J Physiol Regul Integr Comp Physiol. 2011;300:R531-43 pubmed publisher
Srinivasula S, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, et al. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 2001;410:112-6 pubmed
Pan G, O Rourke K, Dixit V. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J Biol Chem. 1998;273:5841-5 pubmed
Li P, Nijhawan D, Budihardjo I, Srinivasula S, Ahmad M, Alnemri E, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479-89 pubmed
Srinivasula S, Fernandes Alnemri T, Zangrilli J, Robertson N, Armstrong R, Wang L, et al. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem. 1996;271:27099-106 pubmed
Duan H, Orth K, Chinnaiyan A, Poirier G, Froelich C, He W, et al. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996;271:16720-4 pubmed

product information

Product ID :

ALX-201-047

Catalog Number :

ALX-201-047-U100

Product Name :

Caspase-9 (human), (recombinant) (active)

Product Type :

Protein

Size :

100 U

list of Pubmed id :

21148478, 11242052, 9488720, 9390557, 8900201, 8663294

Background :

Caspase-9 (also known as Ice-Lap6 and Mch6) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-9 also exists in cells as an inactive proenzyme. During the initiation of apoptosis procaspase-9 is processed at aspartate residues to form active caspase-9. As one of the initiator caspases, active caspase-9 functions to trigger the activation of downstream effector caspases, leading to disassembly of cell structures. The active recombinant caspase-9 is routinely tested for its ability to enzymatically cleave the caspase-9 colorimetric substrate Ac-LEHD-pNA (Prod. No. ALX-260-081).

ALTnames :

ICE-LAP-6, Mch6

Purity :

≥90% (SDS-PAGE)

Buffer :

Lyophilized

Uses :

Useful in screening caspase inhibitors, studying enzyme regulation, determining target substrates or as positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity.

Storage :

-80°C