HOP monoclonal antibody (DS14F5) | Enzo Life Sciences ADI-SRA-1500-D product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HOP monoclonal antibody (DS14F5)

catalog :

ADI-SRA-1500-D

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DS14F5

reactivity :

human, mouse, rat, dogs, chicken, bovine

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

Enzo Life Sciences product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 2c	Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Mol Cell. 2021;: pubmed publisher
western blot; human; loading ...; fig 2b, c	Inda M, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, et al. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020;11:319 pubmed publisher
western blot; human; loading ...; fig 4b	Rodina A, Wang T, Yan P, Gomes E, Dunphy M, Pillarsetty N, et al. The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature. 2016;538:397-401 pubmed publisher
	Veit G, Oliver K, Apaja P, Perdomo D, Bidaud Meynard A, Lin S, et al. Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect. PLoS Biol. 2016;14:e1002462 pubmed publisher
	Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, et al. Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. Eur J Immunol. 2015;45:2028-41 pubmed publisher
	Wang C, Wu L, Bulek K, Martin B, Zepp J, Kang Z, et al. The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90. Nat Immunol. 2013;14:72-81 pubmed publisher
	Tsutsumi S, Mollapour M, Graf C, Lee C, Scroggins B, Xu W, et al. Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain. Nat Struct Mol Biol. 2009;16:1141-7 pubmed publisher
	Shiotsu Y, Neckers L, Wortman I, An W, Schulte T, Soga S, et al. Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex. Blood. 2000;96:2284-91 pubmed
	Graumann K, Jungbauer A. Quantitative assessment of complex formation of nuclear-receptor accessory proteins. Biochem J. 2000;345 Pt 3:627-36 pubmed
	Dittmar K, Banach M, Galigniana M, Pratt W. The role of DnaJ-like proteins in glucocorticoid receptor.hsp90 heterocomplex assembly by the reconstituted hsp90.p60.hsp70 foldosome complex. J Biol Chem. 1998;273:7358-66 pubmed
	Prapapanich V, Chen S, Smith D. Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly. Mol Cell Biol. 1998;18:944-52 pubmed
	Gebauer M, Zeiner M, Gehring U. Proteins interacting with the molecular chaperone hsp70/hsc70: physical associations and effects on refolding activity. FEBS Lett. 1997;417:109-13 pubmed

product information

Product ID :

ADI-SRA-1500

Catalog Number :

ADI-SRA-1500-D

Product Name :

HOP monoclonal antibody (DS14F5)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

50 µg

list of Pubmed id :

23202271, 19838189, 10979978, 10642522, 9516432, 9447991, 9395086

Clone :

DS14F5

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse, Rat, Xenopus, Sheep, Rabbit, Porcine, Monkey, Mink, Hamster, Guinea pig, Dog, Chicken, Bovine

Background :

Hsp70-Hsp90 Organizing Protein (HOP, p60) is an ~60kDa protein that is a critical intermediate component for the efficient maturation of steroid receptor complexes, serving to recruit Hsp90 to Hsp70-containing complexes. HOP contains three tetratricopeptide repeat (TPR) domains, TPR1, TPR2a, and TPR2b.

ALTnames :

STIP1, STI1, STUB1, p60, CHIP

Immunogen :

Chicken HOP (p60).

Buffer :

Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.

Uses :

Detects a band of ~60kDa by Western blot.

Application Summary :

IHC, IP, WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage