HSP90α polyclonal antibody | Enzo Life Sciences ADI-SPS-771-D product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HSP90α polyclonal antibody

catalog :

ADI-SPS-771-D

quantity :

50 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunohistochemistry

more info or order :

Enzo Life Sciences product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 6a western blot; human; loading ...; fig 5a	Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher
	Saito Y, Akazawa Ogawa Y, Matsumura A, Saigoh K, Itoh S, Sutou K, et al. Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients. Sci Rep. 2016;6:30793 pubmed publisher
	Gaponova A, Nikonova A, Deneka A, Kopp M, Kudinov A, Skobeleva N, et al. A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer. Clin Cancer Res. 2016;22:5120-5129 pubmed publisher

product information

Product ID :

ADI-SPS-771

Catalog Number :

ADI-SPS-771-D

Product Name :

HSP90α polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

50 µg

list of Pubmed id :

17360691, 17304217, 11160250

SPECIES REACTIVITY :

Human, Mouse, Rat, Xenopus, Sheep, Rabbit, Porcine, Monkey, Hamster, Guinea pig, Fish, Dog, Bovine, Beluga

Background :

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

ALTnames :

HSP86, Heat shock protein 90α

Immunogen :

Synthetic peptide corresponding to a portion of mouse Hsp86.

Buffer :

Liquid. In PBS containing 0.09% sodium azide and 50% glycerol.

Uses :

Detects a band of ~90kDa by Western blot.

Application Summary :

IHC, WB, Inhibition assay, Cell migration

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage