HSP90 (human), (native) | Enzo Life Sciences ADI-SPP-770-F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

HSP90 (human), (native)

catalog :

ADI-SPP-770-F

quantity :

200 µg

citations: 8

Reference
Tanaka T, Kajiwara T, Kutomi G, Kurotaki T, Saito K, Kanaseki T, et al. CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitating cross-presentation. Immunol Lett. 2015;167:34-40 pubmed publisher
Ricketts C, Bates W, Reid S. The effects of acute waterborne exposure to sublethal concentrations of molybdenum on the stress response in rainbow trout, Oncorhynchus mykiss. PLoS ONE. 2015;10:e0115334 pubmed publisher
Quintana F, Farez M, Viglietta V, Iglesias A, Merbl Y, Izquierdo G, et al. Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc Natl Acad Sci U S A. 2008;105:18889-94 pubmed publisher
Doong H, Rizzo K, Fang S, Kulpa V, Weissman A, Kohn E. CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. J Biol Chem. 2003;278:28490-500 pubmed
Chiosis G, Lucas B, Shtil A, Huezo H, Rosen N. Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. Bioorg Med Chem. 2002;10:3555-64 pubmed
Luo L, Herrera I, Soosaipillai A, Diamandis E. Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library. Br J Cancer. 2002;87:339-43 pubmed
Gyoo Park S, Kyung Rho J, Jung G. Hsp90 makes the human HBV Pol competent for in vitro priming rather than maintaining the human HBV Pol/pregenomic RNA complex. Arch Biochem Biophys. 2002;401:99-107 pubmed
Dean D, Tytell M. Hsp25 and -90 immunoreactivity in the normal rat eye. Invest Ophthalmol Vis Sci. 2001;42:3031-40 pubmed

product information

Product ID :

ADI-SPP-770

Catalog Number :

ADI-SPP-770-F

Product Name :

HSP90 (human), (native)

Product Type :

Protein

Size :

200 µg

list of Pubmed id :

26141624, 25629693, 19028871, 12750378, 12213470, 12177805, 12054492, 11687552

Background :

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

ALTnames :

HSP86, Heat shock protein 90

Purity :

≥90% (SDS-PAGE; Western blot)

Buffer :

Liquid. In 50mM TRIS-HCl, pH 7.5, containing 1.0mM DTT and 100mM sodium chloride.

Uses :

Western blot control.

Application Summary :

ELISA, WB, Antigen microarray

Storage :

-80°C