HSC70/HSP73 (bovine), (recombinant) | Enzo Life Sciences ADI-SPP-751-F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

HSC70/HSP73 (bovine), (recombinant)

catalog :

ADI-SPP-751-F

quantity :

200 µg

citations: 6

Reference
Mandelin J, Cardo Vila M, Driessen W, Mathew P, Navone N, Lin S, et al. Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors. Proc Natl Acad Sci U S A. 2015;112:3776-81 pubmed publisher
Halpin P, Sorte C, Hofmann G, Menge B. Patterns of variation in levels of hsp70 in natural rocky shore populations from microscales to mesoscales. Integr Comp Biol. 2002;42:815-24 pubmed publisher
Cuzzocrea S, Ianaro A, Wayman N, Mazzon E, Pisano B, Dugo L, et al. The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. Br J Pharmacol. 2003;138:678-88 pubmed
Angeletti P, Walker D, Panganiban A. Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity. Cell Stress Chaperones. 2002;7:258-68 pubmed
Scott M, Locke M, Buck L. Tissue-specific expression of inducible and constitutive Hsp70 isoforms in the western painted turtle. J Exp Biol. 2003;206:303-11 pubmed
Maier J, Haug M, Föll J, Beck H, Kalbacher H, Rammensee H, et al. Possible association of non-binding of HSP70 to HLA-DRB1 peptide sequences and protection from rheumatoid arthritis. Immunogenetics. 2002;54:67-73 pubmed

product information

Product ID :

ADI-SPP-751

Catalog Number :

ADI-SPP-751-F

Product Name :

HSC70/HSP73 (bovine), (recombinant)

Product Type :

Protein

Size :

200 µg

list of Pubmed id :

25762070, 21708780, 12598422, 12482202, 12477900, 12037598

Background :

The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

ALTnames :

Heat shock cognate 71 kDa protein, Heat shock 70 kDa protein 8, HSPA8

Purity :

≥90% (SDS-PAGE; Western blot)

Buffer :

Liquid. In 30mM TRIS-HCl, pH 7.5, containing 1.0mM EDTA, 2.0mM DTT, and 300mM sodium chloride.

Uses :

ATPase activity assay (positive). Western blot control.

Application Summary :

WB, Activity assay

Storage :

-80°C