HSP27 (phospho) (human), (recombinant) | Enzo Life Sciences ADI-SPP-716-F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

HSP27 (phospho) (human), (recombinant)

catalog :

ADI-SPP-716-F

quantity :

200 µg

citations: 2

Reference
Daswani B, Gupta M, Gavali S, Desai M, Sathe G, Patil A, et al. Monocyte Proteomics Reveals Involvement of Phosphorylated HSP27 in the Pathogenesis of Osteoporosis. Dis Markers. 2015;2015:196589 pubmed publisher
Tokuda H, Kuroyanagi G, Tsujimoto M, Enomoto Y, Matsushima Nishiwaki R, Onuma T, et al. Release of Phosphorylated HSP27 (HSPB1) from Platelets Is Accompanied with the Acceleration of Aggregation in Diabetic Patients. PLoS ONE. 2015;10:e0128977 pubmed publisher

product information

Product ID :

ADI-SPP-716

Catalog Number :

ADI-SPP-716-F

Product Name :

HSP27 (phospho) (human), (recombinant)

Product Type :

Protein

Size :

200 µg

list of Pubmed id :

26063949, 26046355

Background :

Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHSP), which also includes aB-crystallin. It is characterized by a conserved C-terminal a-crystallin domain consisting of two antiparallel β-sheets that promote oligomer formation required for its primary chaperone function as inhibitors of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser-15, Ser-78, and Ser-82, by a variety of protein kinases including MAPKAPK-3, PKAcα, p70S6K, PKD I, and PKCδ. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Antiapoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of AKT, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

ALTnames :

HspB1, Heat shock protein 27

Purity :

≥90% (SDS-PAGE; Western blot)

Buffer :

Liquid. In 50mM TRIS, pH 7.5, containing 0.1mM EGTA, 1mM EDTA, 15mM DTT, 100mM ATP, and 15mM magnesium chloride.

Uses :

Western blot control.

Application Summary :

Storage :

-80°C