HSP27 (human), (recombinant) | Enzo Life Sciences ADI-SPP-715-F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

HSP27 (human), (recombinant)

catalog :

ADI-SPP-715-F

quantity :

200 µg

citations: 9

Reference
Gehrmann M, Stangl S, Foulds G, Oellinger R, Breuninger S, Rad R, et al. Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide. PLoS ONE. 2014;9:e105344 pubmed publisher
Quintana F, Farez M, Viglietta V, Iglesias A, Merbl Y, Izquierdo G, et al. Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc Natl Acad Sci U S A. 2008;105:18889-94 pubmed publisher
Paulsen G, Vissing K, Kalhovde J, Ugelstad I, Bayer M, Kadi F, et al. Maximal eccentric exercise induces a rapid accumulation of small heat shock proteins on myofibrils and a delayed HSP70 response in humans. Am J Physiol Regul Integr Comp Physiol. 2007;293:R844-53 pubmed
Pagliuca M, Lerose R, Cigliano S, Leone A. Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity. FEBS Lett. 2003;541:11-5 pubmed
Matsuda K, Idezawa T, You X, Kothari N, Fan H, Korc M. Multiple mitogenic pathways in pancreatic cancer cells are blocked by a truncated epidermal growth factor receptor. Cancer Res. 2002;62:5611-7 pubmed
Suzuki A, Guicheux J, Palmer G, Miura Y, Oiso Y, Bonjour J, et al. Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation. Bone. 2002;30:91-8 pubmed
Salvador L, Park Y, Cottom J, Maizels E, Jones J, Schillace R, et al. Follicle-stimulating hormone stimulates protein kinase A-mediated histone H3 phosphorylation and acetylation leading to select gene activation in ovarian granulosa cells. J Biol Chem. 2001;276:40146-55 pubmed
Herrera B, Fernandez M, Roncero C, Ventura J, Porras A, Valladares A, et al. Activation of p38MAPK by TGF-beta in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death. FEBS Lett. 2001;499:225-9 pubmed
Valladares A, Roncero C, Benito M, Porras A. TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK. FEBS Lett. 2001;493:6-11 pubmed

product information

Product ID :

ADI-SPP-715

Catalog Number :

ADI-SPP-715-F

Product Name :

HSP27 (human), (recombinant)

Product Type :

Protein

Size :

200 µg

list of Pubmed id :

25165986, 19028871, 17522120, 12706811, 12359775, 11792570, 11498542, 11423121, 11277995

Background :

Human Hsp27, mouse Hsp25 and ab-crystallin are part of a diverse family of small heat shock proteins which are produced in all organisms. They function as chaperone-like proteins by binding unfolded polypeptides and preventing uncontrolled protein aggregation. Hsp27 is believed to exist mainly as oligomers of as many as 8-40 Hsp27 protein monomers in cells. Data suggests that the large oligomers of Hsp27 have a chaperone-like activity by serving as a site where unfolded proteins may bind until ATP and Hsp70-dependent refolding can occur. The phosphorylation and oligomerization state of Hsp27 has been suggested to regulate microfilament organization, since only the nonphosphorylated lower molecular weight forms of Hsp27 bind actin barbed ends and inhibit polymerization. Hsp27 is also believed to protect cells by enhancing cellular glutathione levels, as elevated glutathione levels have been measured in cells overexpressing Hsp27. Data from studies using wild-type Hsp27 and mutant forms in which the serine phosphorylation sites were

ALTnames :

HspB1, Heat shock protein 27

Purity :

≥90% (SDS-PAGE; Western blot)

Buffer :

Liquid. In 20mM TRIS, pH 7.5, containing 10mM sodium chloride, 1mM EDTA, and 1mM DTT.

Uses :

Western blot control.

Application Summary :

Storage :

-80°C