HSP90β monoclonal antibody (K3705) | Enzo Life Sciences ADI-SPA-842-D product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HSP90β monoclonal antibody (K3705)

catalog :

ADI-SPA-842-D

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

K3705

reactivity :

human, mouse, rat, dogs, chicken, bovine

application :

western blot, immunohistochemistry, flow cytometry

more info or order :

Enzo Life Sciences product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2	Bzowska M, Nogieć A, Bania K, Zygmunt M, Zarebski M, Dobrucki J, et al. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages. J Leukoc Biol. 2017;102:763-774 pubmed publisher
western blot; rat	Winsauer P, Filipeanu C, Weed P, Sutton J. Hormonal status and age differentially affect tolerance to the disruptive effects of delta-9-tetrahydrocannabinol (Î”(9)-THC) on learning in female rats. Front Pharmacol. 2015;6:133 pubmed publisher
western blot; mouse	Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, et al. Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. Eur J Immunol. 2015;45:2028-41 pubmed publisher
western blot; human; fig s3	MorlÃ© A, Garrido C, Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. Cell Death Dis. 2015;6:e1633 pubmed publisher
	Thirstrup K, Sotty F, Montezinho L, Badolo L, Thougaard A, KristjÃ¡nsson M, et al. Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain. Pharmacol Res. 2016;104:197-205 pubmed publisher

product information

Product ID :

ADI-SPA-842

Catalog Number :

ADI-SPA-842-D

Product Name :

HSP90β monoclonal antibody (K3705)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

50 µg

Clone :

K3705

Isotype :

IgM

SPECIES REACTIVITY :

Human, Mouse, Rat, Sheep, Porcine, Hamster, Guinea pig, Dog, Chicken, Bovine

Background :

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

ALTnames :

HSP86, Heat shock protein 90β

Immunogen :

Recombinant human HSP90β.

Buffer :

Liquid. In saline, pH 6.9, containing 0.1% sodium azide.

Uses :

Detects a band of ~90kDa by Western blot.

Application Summary :

IHC, WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage