HSP90α monoclonal antibody (9D2) (PE conjugate) | Enzo Life Sciences ADI-SPA-840PE-0200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HSP90α monoclonal antibody (9D2) (PE conjugate)

catalog :

ADI-SPA-840PE-0200

quantity :

200 µg

clonality :

monoclonal

host :

rat

conjugate :

clone name :

9D2

application :

flow cytometry

citations: 5

Reference
Veit G, Oliver K, Apaja P, Perdomo D, Bidaud Meynard A, Lin S, et al. Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect. PLoS Biol. 2016;14:e1002462 pubmed publisher
Zhang X, Qian Z, Zhu H, Tang S, Wu D, Zhang M, et al. HSP90 gene expression induced by aspirin is associated with damage remission in a chicken myocardial cell culture exposed to heat stress. Br Poult Sci. 2016;57:462-73 pubmed publisher
Zhang X, Zhu H, Qian Z, Tang S, Wu D, Kemper N, et al. The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells. J Vet Sci. 2016;17:35-44 pubmed publisher
Joshi A, Barabutis N, Birmpas C, Dimitropoulou C, Thangjam G, Cherian Shaw M, et al. Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1410-9 pubmed publisher
Zeng X, Wang H, Bai F, Zhou X, Li S, Ren L, et al. Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target. Br J Pharmacol. 2015;172:4303-18 pubmed publisher

product information

Product ID :

ADI-SPA-840PE

Catalog Number :

ADI-SPA-840PE-0200

Product Name :

HSP90α monoclonal antibody (9D2) (PE conjugate)

Host species :

Rat

Clonality :

Monoclonal

Conjugation :

Product Type :

Antibody

Size :

200 µg

Clone :

9D2

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Chicken

Background :

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

ALTnames :

HSP86, Heat shock protein 90α

Immunogen :

Purified Hsp90 isolated from human therapeutic orchiectomy specimens.

Buffer :

Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.

Uses :

Detects a band of ~90kDa by Western blot.

Application Summary :

Storage :

+4°C