HSP90α monoclonal antibody (K41009) | Enzo Life Sciences ADI-SPA-839-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HSP90α monoclonal antibody (K41009)

catalog :

ADI-SPA-839-050

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

K41009

reactivity :

human, mouse, rat

application :

western blot

citations: 1

Reference
Bonvini P, Gastaldi T, Falini B, Rosolen A. Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamyc. Cancer Res. 2002;62:1559-66 pubmed

product information

Product ID :

ADI-SPA-839

Catalog Number :

ADI-SPA-839-050

Product Name :

HSP90α monoclonal antibody (K41009)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

50 µg

list of Pubmed id :

11888936

Clone :

K41009

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Mouse, Rat, Rabbit

Background :

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90α/β), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

ALTnames :

HSP86, Heat shock protein 90α

Immunogen :

Recombinant human Hsp90α.

Buffer :

Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.

Uses :

Detects a band of ~90kDa by Western blot.

Application Summary :

Storage :

-20°C