HSP90 monoclonal antibody (16F1) (biotin conjugate) | Enzo Life Sciences ADI-SPA-835B-E product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HSP90 monoclonal antibody (16F1) (biotin conjugate)

catalog :

ADI-SPA-835B-E

quantity :

100 µg

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

16F1

reactivity :

human, mouse, rat

application :

western blot

citations: 9

Reference
Conos S, Lawlor K, Vaux D, Vince J, Lindqvist L. Cell death is not essential for caspase-1-mediated interleukin-1Î² activation and secretion. Cell Death Differ. 2016;23:1827-1838 pubmed publisher
Andreeva N, Zatsepina O, Garbuz D, Evgen ev M, Belyavsky A. Recombinant HSP70 and mild heat shock stimulate growth of aged mesenchymal stem cells. Cell Stress Chaperones. 2016;21:727-33 pubmed publisher
Kavlashvili T, Jia Y, Dai D, Meng X, Thiel K, Leslie K, et al. Inverse Relationship between Progesterone Receptor and Myc in Endometrial Cancer. PLoS ONE. 2016;11:e0148912 pubmed publisher
Jacobsen A, Lowes K, Tanzer M, Lucet I, Hildebrand J, Petrie E, et al. HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. Cell Death Dis. 2016;7:e2051 pubmed publisher
Clemente Vicario F, Alvarez C, ROWELL J, Roy S, London C, Kisseberth W, et al. Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines. PLoS ONE. 2015;10:e0142007 pubmed publisher
Amlie Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, et al. Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin. PLoS ONE. 2015;10:e0141836 pubmed publisher
Pearce M, Spartz E, Hong W, Luo L, Kopito R. Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain. Nat Commun. 2015;6:6768 pubmed publisher
Nanduri P, Hao R, Fitzpatrick T, Yao T. Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. J Biol Chem. 2015;290:9455-64 pubmed publisher
Middlekauff H, Vigna C, Verity M, Fonarow G, Horwich T, Hamilton M, et al. Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism?. J Card Fail. 2012;18:724-33 pubmed publisher

product information

Product ID :

ADI-SPA-835B

Catalog Number :

ADI-SPA-835B-E

Product Name :

HSP90 monoclonal antibody (16F1) (biotin conjugate)

Host species :

Rat

Clonality :

Monoclonal

Conjugation :

Biotin

Product Type :

Antibody

Size :

100 µg

Clone :

16F1

Isotype :

IgG2a

SPECIES REACTIVITY :

Human, Mouse, Rat, Xenopus, Sheep, Scallop, Rabbit, Plant, Porcine, Opossum, Mussel, Monkey, Hamster, Guinea pig, Fish, Drosophila, Dog, Chicken, Bovine, Beluga

Background :

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

ALTnames :

Heat shock protein 90

Immunogen :

Native human Hsp90.

Buffer :

Liquid. In PBS containing 0.09% sodium azide.

Uses :

Detects a band of ~90kDa by Western blot.

Application Summary :

Storage :

-20°C