HSP90 monoclonal antibody (2D11B9) | Enzo Life Sciences ADI-SPA-831-050 product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HSP90 monoclonal antibody (2D11B9)

catalog :

ADI-SPA-831-050

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D11B9

reactivity :

human, mouse, rat, dogs

application :

western blot

more info or order :

Enzo Life Sciences product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:3000	Moura C, Lollo P, Morato P, Nisishima L, Carneiro E, Amaya Farfan J. Whey protein hydrolysate enhances HSP90 but does not alter HSP60 and HSP25 in skeletal muscle of rats. PLoS ONE. 2014;9:e83437 pubmed publisher
	Capece T, Walling B, Lim K, Kim K, Bae S, Chung H, et al. A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation. J Cell Biol. 2017;216:3817-3829 pubmed publisher
	Shi L, Gehin T, Chevolot Y, Souteyrand E, MangÃ© A, Solassol J, et al. Anti-heat shock protein autoantibody profiling in breast cancer using customized protein microarray. Anal Bioanal Chem. 2016;408:1497-506 pubmed publisher
	Bach D, Kim S, Hong J, Park H, Oh D, Lee S. Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1Î± and Induces Apoptosis in Human Colorectal Cancer Cells. Mar Drugs. 2015;13:6962-76 pubmed publisher
	White P, Subramanian C, Zhu Q, Zhang H, Zhao H, Gallagher R, et al. Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion. Surgery. 2016;159:142-51 pubmed publisher
	Marineli R, Moura C, Moraes Ã, Lenquiste S, Lollo P, Morato P, et al. Chia (Salvia hispanica L.) enhances HSP, PGC-1Î± expressions and improves glucose tolerance in diet-induced obese rats. Nutrition. 2015;31:740-8 pubmed publisher

product information

Product ID :

ADI-SPA-831

Catalog Number :

ADI-SPA-831-050

Product Name :

HSP90 monoclonal antibody (2D11B9)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

50 µg

list of Pubmed id :

26610526, 26542767

Clone :

2D11B9

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse, Rat, Sheep, Porcine, Monkey, Horse, Hamster, Guinea pig, Fish, Drosophila, Dog

Background :

The 90kDa molecular chaperone family includes 90kDa heat shock protein Hsp90 and 94kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells contain isoforms Hsp90α and Hsp90β, encoded by separate genes. The amino acid sequences of human and yeast Hsp90α are 85% and 90% homologous to those of Hsp90β, respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 functions as part of the cell’s powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions. In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signalling and cell cycle control. In this context, researchers identified key regulatory proteins as substrates of Hsp90, including steroid receptors, cell cycle kinases involved in signal transduction, and p53. Hsp90 may act as a capacitor for morphological evolution by buffering widespread variation, potentially affecting morphogenic pathways. When temperature and other stress factors compromise Drosophilia Hsp90 buffering, cryptic variant expression occurs, and selection can lead to the continued expression of these traits, even after Hsp90 function is restored.

ALTnames :

Heat shock protein 90

Immunogen :

Recombinant human Hsp90.

Buffer :

Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.

Uses :

Detects a band of ~92kDa by Western blot.

Application Summary :

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage