HSP90 monoclonal antibody (AC88) (PE conjugate) | Enzo Life Sciences ADI-SPA-830PE-D product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HSP90 monoclonal antibody (AC88) (PE conjugate)

catalog :

ADI-SPA-830PE-D

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

AC88

The same clone is also sold as:

Abcam: ab13492
Santa Cruz Biotechnology: sc-59577
Novus Biologicals: NB100-1972

reactivity :

human, mouse, rat, dogs, chicken

application :

western blot, flow cytometry

more info or order :

Enzo Life Sciences product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1	Tribollet V, Barenton B, Kroiss A, Vincent S, Zhang L, Forcet C, et al. miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERR?. PLoS ONE. 2016;11:e0156445 pubmed publisher
western blot; human; fig 5	Lee J, Kuo C, Tsai S, Cheng S, Chen S, Chan H, et al. Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells. Front Pharmacol. 2016;7:81 pubmed publisher
western blot; mouse	Gong J, Weng D, Eguchi T, Murshid A, Sherman M, Song B, et al. Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene. 2015;34:5460-71 pubmed publisher
	Hogg S, Newbold A, Vervoort S, Cluse L, Martin B, Gregory G, et al. BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members. Mol Cancer Ther. 2016;15:2030-41 pubmed publisher
	Kruger L, O Malley H, Hull J, Kleeman A, Patino G, Isom L. ?1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. J Neurosci. 2016;36:6213-24 pubmed publisher
	Huang K, Chen Z, Jiang Y, Akare S, Kolber Simonds D, Condon K, et al. Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61. Mol Cancer Ther. 2016;15:1208-16 pubmed publisher
	Kasza A, Hunya A, Frank Z, Fulop F, Torok Z, Balogh G, et al. Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;53:557-71 pubmed publisher
	Kallifatidis G, Munoz D, Singh R, Salazar N, Hoy J, Lokeshwar B. Î²-Arrestin-2 Counters CXCR7-Mediated EGFR Transactivation and Proliferation. Mol Cancer Res. 2016;14:493-503 pubmed publisher
	MikyÅ¡kovÃ¡ R, Å tÄ›pÃ¡nek I, IndrovÃ¡ M, BieblovÃ¡ J, Å ÃmovÃ¡ J, TruxovÃ¡ I, et al. Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy. Int J Oncol. 2016;48:953-64 pubmed publisher
	Carter E, Gupta N, Ragsdale S. High Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbÎ² Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor. J Biol Chem. 2016;291:2196-222 pubmed publisher
	Baker A, Gregory G, Verbrugge I, Kats L, Hilton J, Vidacs E, et al. The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia. Cancer Res. 2016;76:1158-69 pubmed publisher
	Matthews G, Mehdipour P, Cluse L, Falkenberg K, Wang E, Roth M, et al. Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. Blood. 2015;126:2392-403 pubmed publisher
	Saeed H, Shalaby M, Embaby A, Ismael M, Pathan A, Ataya F, et al. The Arabian camel Camelus dromedarius heat shock protein 90Î±: cDNA cloning, characterization and expression. Int J Biol Macromol. 2015;81:195-204 pubmed publisher
	Di Giancamillo A, Rossi R, Pastorelli G, Deponti D, Carollo V, Casamassima D, et al. The effects of dietary verbascoside on blood and liver oxidative stress status induced by a high n-6 polyunsaturated fatty acids diet in piglets. J Anim Sci. 2015;93:2849-59 pubmed publisher
	Dudek PeriÄ‡ A, Ferreira G, Muchowicz A, Wouters J, Prada N, Martin S, et al. Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin. Cancer Res. 2015;75:1603-14 pubmed publisher
	Martin S, Dudek PeriÄ‡ A, Maes H, Garg A, Gabrysiak M, Demirsoy S, et al. Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells. Biochem Pharmacol. 2015;93:290-304 pubmed publisher
	Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, et al. Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes. Cell Stress Chaperones. 2012;17:757-63 pubmed publisher
	Peng H, Morishima Y, Pratt W, Osawa Y. Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination. J Biol Chem. 2012;287:1556-65 pubmed publisher

product information

Product ID :

ADI-SPA-830PE

Catalog Number :

ADI-SPA-830PE-D

Product Name :

HSP90 monoclonal antibody (AC88) (PE conjugate)

Host species :

Mouse

Clonality :

Monoclonal

Conjugation :

Product Type :

Antibody

Size :

50 µg

Clone :

AC88

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Mouse, Rat, Fusobacterium nucleatum, Water mold, Sheep, Scallop, Rabbit, Porcine, Mussel, Monkey, Mycobacterium leprae, Hamster, Guinea pig, Fish, E. coli, Dog, Chicken, C. elegans, Beluga

Background :

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

ALTnames :

Heat shock protein 90

Immunogen :

Achlya ambisexualis (water mold) Hsp90.

Buffer :

Liquid. In PBS containing 0.09% sodium azide.

Application Summary :

Storage :

+4°C

more info or order :

Enzo Life Sciences product webpage