product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
HSC70 (plant) monoclonal antibody (5B7)
catalog :
ADI-SPA-817-D
quantity :
50 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
5B7
reactivity :
human
application :
western blot, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Enzo Life Sciences product webpage
citations: 4
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:250; fig 2
Trieb K, Sulzbacher I, Kubista B. Recurrence rate and progression of chondrosarcoma is correlated with heat shock protein expression. Oncol Lett. 2016;11:521-524 pubmed
Gou M, Zhang Z, Zhang N, Huang Q, Monaghan J, Yang H, et al. Opposing Effects on Two Phases of Defense Responses from Concerted Actions of HEAT SHOCK COGNATE70 and BONZAI1 in Arabidopsis. Plant Physiol. 2015;169:2304-23 pubmed publisher
Young P, Bartel B. Pexophagy and peroxisomal protein turnover in plants. Biochim Biophys Acta. 2016;1863:999-1005 pubmed publisher
Anderson J, Li Q, Haskell D, Guy C. Structural organization of the spinach endoplasmic reticulum-luminal 70-kilodalton heat-shock cognate gene and expression of 70-kilodalton heat-shock genes during cold acclimation. Plant Physiol. 1994;104:1359-70 pubmed
product information
Product ID :
ADI-SPA-817
Catalog Number :
ADI-SPA-817-D
Product Name :
HSC70 (plant) monoclonal antibody (5B7)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
50 µg
list of Pubmed id :
26348128, 8016266
Clone :
5B7
Isotype :
IgG1
SPECIES REACTIVITY :
Plant
Background :
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
ALTnames :
Heat shock protein 70, Hsc70, Hsp73
Immunogen :
Recombinant spinach Hsc70 (Hsp73).
Buffer :
Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Uses :
Detects a band of ~70kDa by Western blot.
Application Summary :
IP, WB
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.