product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Hsp70, HspA1A, Heat shock protein 70, HspA1B, Hsp72
catalog :
ADI-SPA-812
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
more info or order :
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 6f
Wani A, Zhu J, ULRICH J, Eteleeb A, Sauerbeck A, Reitz S, et al. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Rep. 2021;36:109399 pubmed publisher
  • western blot; rat; loading ...; fig 5c
Eftekharzadeh B, Banduseela V, Chiesa G, Martínez Cristóbal P, Rauch J, Nath S, et al. Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nat Commun. 2019;10:3562 pubmed publisher
  • western blot; human; loading ...; fig 3b
Tracz Gaszewska Z, Klimczak M, Biecek P, Herok M, Kosiński M, Olszewski M, et al. Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation. Oncotarget. 2017;8:82123-82143 pubmed publisher
  • western blot; mouse; fig 2b
Kennedy T, Swiderski K, Murphy K, Gehrig S, Curl C, Chandramouli C, et al. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. Am J Pathol. 2016;186:3246-3260 pubmed publisher
  • western blot; human; 1:4000; loading ...; fig 8
Peake J, Roberts L, Figueiredo V, Egner I, Krog S, Aas S, et al. The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise. J Physiol. 2017;595:695-711 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, et al. BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1. Neuroscience. 2016;327:20-31 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher
  • western blot; rat; fig 1
Goto A, Egawa T, Sakon I, Oshima R, Ito K, Serizawa Y, et al. Heat stress acutely activates insulin-independent glucose transport and 5'-AMP-activated protein kinase prior to an increase in HSP72 protein in rat skeletal muscle. Physiol Rep. 2015;3: pubmed publisher
  • western blot; mouse; fig 3d
Joly A, Deepti A, Seignez A, Goloudina A, Hebrard S, Schmitt E, et al. The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development. Oncogene. 2016;35:2842-51 pubmed publisher
  • immunocytochemistry; human; fig s4b
Hobbs R, DePianto D, Jacob J, Han M, Chung B, Batazzi A, et al. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015;47:933-8 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 6
Chittoor Vinod V, Lee S, Judge S, Notterpek L. Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22. ASN Neuro. 2015;7: pubmed publisher
  • western blot; human; loading ...; fig 7
Sajish M, Schimmel P. A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Nature. 2015;519:370-3 pubmed publisher
  • immunocytochemistry; human; 1:200
Rogon C, Ulbricht A, Hesse M, Alberti S, Vijayaraj P, Best D, et al. HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Mol Biol Cell. 2014;25:2260-71 pubmed publisher
Park Y, Franz C, Ryu H, Luan H, Cotton K, Kim J, et al. Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids. Sci Adv. 2021;7: pubmed publisher
Wu H, Niu K, Lin C, Lin H, Chang C, Wang C. HSP-70-Mediated Hyperbaric Oxygen Reduces Brain and Pulmonary Edema and Cognitive Deficits in Rats in a Simulated High-Altitude Exposure. Biomed Res Int. 2018;2018:4608150 pubmed publisher
Kim H, Lee J, Park K, Kim W, Roh G. A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death. BMC Neurosci. 2016;17:33 pubmed publisher
Delenclos M, Trendafilova T, Jones D, Moussaud S, Baine A, Yue M, et al. A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo. Front Neurosci. 2015;9:511 pubmed publisher
Ohno Y, Egawa T, Yokoyama S, Nakai A, Sugiura T, Ohira Y, et al. Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice. Acta Physiol (Oxf). 2015;215:191-203 pubmed publisher
Centenera M, Carter S, Gillis J, Marrocco Tallarigo D, Grose R, Tilley W, et al. Co-targeting AR and HSP90 suppresses prostate cancer cell growth and prevents resistance mechanisms. Endocr Relat Cancer. 2015;22:805-18 pubmed publisher
Yazama F, Sato H, Sonoda T. Malfunction of spermatogenesis in experimental ischemic mice. J Reprod Dev. 2015;61:399-406 pubmed publisher
Kitagawa T, Okita H, Baron B, Tokuda K, Nakamura M, Wang Y, et al. Mutant screening for oncogenes of Ewing's sarcoma using yeast. Appl Microbiol Biotechnol. 2015;99:6737-44 pubmed publisher
Moussaud S, Malany S, Mehta A, Vasile S, Smith L, McLean P. Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies. Expert Opin Ther Targets. 2015;19:589-603 pubmed publisher
Chai R, Kouspou M, Lang B, Nguyen C, van der Kraan A, Vieusseux J, et al. Molecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent manner. J Biol Chem. 2014;289:13602-14 pubmed publisher
Cushman Nick M, Bonini N, Shorter J. Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model. PLoS Genet. 2013;9:e1003781 pubmed publisher
Park Y, Zhao X, Norton M, Taylor J, Eisenberg E, Greene L. Huntingtin fragments and SOD1 mutants form soluble oligomers in the cell. PLoS ONE. 2012;7:e40329 pubmed publisher
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.