HSP70/HSP72 polyclonal antibody | Enzo Life Sciences ADI-SPA-811-D product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HSP70/HSP72 polyclonal antibody

catalog :

ADI-SPA-811-D

quantity :

50 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunoprecipitation

citations: 1

Reference
Liebelt F, Sebastian R, Moore C, Mulder M, Ovaa H, Shoulders M, et al. SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock. Cell Rep. 2019;26:236-249.e4 pubmed publisher

product information

Product ID :

ADI-SPA-811

Catalog Number :

ADI-SPA-811-D

Product Name :

HSP70/HSP72 polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

50 µg

list of Pubmed id :

26267515, 21034357, 17409277

SPECIES REACTIVITY :

Human, Mouse, Rat, Sheep, Porcine, Monkey, Hamster, Dog, Bovine, Beluga

Background :

The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

ALTnames :

Hsp70, HspA1A, Heat shock protein 70, HspA1B, Hsp72

Immunogen :

Synthetic peptide corresponding to a portion of human Hsp70.

Buffer :

Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.

Uses :

Detects a band of ~70kDa by Western blot.

Application Summary :

IP, WB

Storage :

-20°C