This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
HSP27 monoclonal antibody (G3.1) (DyLight™ 488 conjugate)
catalog :
ADI-SPA-800-488-E
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
DyLight488
clone name :
G3.1

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
citations: 5
Reference
Homa J, Ortmann W, Kolaczkowska E. Conservative Mechanisms of Extracellular Trap Formation by Annelida Eisenia andrei: Serine Protease Activity Requirement. PLoS ONE. 2016;11:e0159031 pubmed publisher
Qvit N, Joshi A, Cunningham A, Ferreira J, Mochly Rosen D. Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death. J Biol Chem. 2016;291:13608-21 pubmed publisher
Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, et al. IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis. Sci Rep. 2016;6:19174 pubmed publisher
Shi L, Gehin T, Chevolot Y, Souteyrand E, Mangé A, Solassol J, et al. Anti-heat shock protein autoantibody profiling in breast cancer using customized protein microarray. Anal Bioanal Chem. 2016;408:1497-506 pubmed publisher
Xiong R, Zhou W, Siegel D, Kitson R, Freed C, Moody C, et al. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. Mol Pharmacol. 2015;88:1045-54 pubmed publisher
product information
Product ID :
ADI-SPA-800-488
Catalog Number :
ADI-SPA-800-488-E
Product Name :
HSP27 monoclonal antibody (G3.1) (DyLight™ 488 conjugate)
Host species :
Mouse
Clonality :
Monoclonal
Conjugation :
DyLight™ 488
Product Type :
Antibody
Size :
100 µg
Clone :
G3.1
Isotype :
IgG1
SPECIES REACTIVITY :
Human, Mouse, Rat, Monkey, Fish, Bovine
Background :
Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.
ALTnames :
HspB1, Heat shock protein 27
Immunogen :
Native human Hsp27.
Buffer :
Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
Application Summary :
FC
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.