Calreticulin monoclonal antibody (FMC 75) (DyLight™ 488 conjugate) | Enzo Life Sciences ADI-SPA-601-488-D product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Calreticulin monoclonal antibody (FMC 75) (DyLight™ 488 conjugate)

catalog :

ADI-SPA-601-488-D

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

DyLight488

clone name :

FMC 75

The same clone is also sold as:

Invitrogen: MA1-91034
Abcam: ab22683

reactivity :

human

application :

flow cytometry

citations: 1

Reference
MikyÅ¡kovÃ¡ R, Å tÄ›pÃ¡nek I, IndrovÃ¡ M, BieblovÃ¡ J, Å ÃmovÃ¡ J, TruxovÃ¡ I, et al. Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy. Int J Oncol. 2016;48:953-64 pubmed publisher

product information

Product ID :

ADI-SPA-601-488

Catalog Number :

ADI-SPA-601-488-D

Product Name :

Calreticulin monoclonal antibody (FMC 75) (DyLight™ 488 conjugate)

Host species :

Mouse

Clonality :

Monoclonal

Conjugation :

DyLight™ 488

Product Type :

Antibody

Size :

50 µg

Clone :

FMC 75

Isotype :

IgG1

SPECIES REACTIVITY :

Human, Monkey

Background :

The multifunctional, multi -compartmental protein Calreticulin (Crt) functions as a soluble molecular chaperone of new or misfolded proteins, as well as a Ca2+-binding protein. Most abundant in the ER lumen, Crt expression also occurs in other membrane-bound organelles, the cell surface, and extracellularly. Also known as CRP-55, calregulin and HACBP (high affinity calcium-binding protein), Crt contains the ER-retrieval sequence, KDEL, and is the solub le paralog of the ER membrane protein Calnexin (Cnx). Crt's three domains include a 180 residue N-terminal domain, a proline-rich Pdomainresidues 189 -288) that binds Ca2+ with high affinity and shares homology with Cnx and calmegin, and a 110 residue C-terminal domain that binds Ca2+ with low affinity but high capacity. The P-domain may interact with the co-chaperone ERp57 (Grp58), a thiol reductase. The NMR structure of the P -domain consists of an extended hairpin that appears to form a curved protrusion from the Crt core domain. Both Crt and its membrane bound homolog CNX interact with proteins and glycoproteins possessing monoglucosylated N -glycans. The Crt/Cnx cycle promotes correct folding, inhibits aggregation of folding intermediates, blocks premature oligomerization, regulates ER degradation, and prevents incompletely folded glycoproteins from exiting to the Golgi complex. Crt also appears to function as an auto-antigen in systemic lupus erythematosus, rheumatoid arthritis, celiac disease, complete congenital heart block, and halothane hepatitis. A diversity of additional functions attributed to Crt includes adhesion, blood function, and cardiac and neuronal development gene expression.

ALTnames :

CALR, CRT

Immunogen :

Recombinant calreticulin.

Buffer :

Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.

Uses :

Predicted MW of ~63kDa.

Application Summary :

Storage :

-20°C