HO-1 monoclonal antibody (HO-1-2) (PE conjugate) | Enzo Life Sciences ADI-OSA-111PE-D product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

HO-1 monoclonal antibody (HO-1-2) (PE conjugate)

catalog :

ADI-OSA-111PE-D

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

HO-1-2

The same clone is also sold as:

Boster: M00253-1
Abcam: ab83214, ab69545

reactivity :

human, mouse, rat, dogs

application :

flow cytometry

citations: 5

Reference
Zhao H, Kalish F, Wong R, Stevenson D. Infiltration of myeloid cells in the pregnant uterus is affected by heme oxygenase-1. J Leukoc Biol. 2017;101:217-226 pubmed publisher
Belcher J, Chen C, Nguyen J, Zhang P, Abdulla F, Nguyen P, et al. Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate. Antioxid Redox Signal. 2017;26:748-762 pubmed publisher
Choi E, Park H, Sul O, Rajasekaran M, Yu R, Choi H. Carbon monoxide reverses adipose tissue inflammation and insulin resistance upon loss of ovarian function. Am J Physiol Endocrinol Metab. 2015;308:E621-30 pubmed publisher
Najar M, Raicevic G, Fayyad Kazan H, Kazan H, De Bruyn C, Bron D, et al. Immune-related antigens, surface molecules and regulatory factors in human-derived mesenchymal stromal cells: the expression and impact of inflammatory priming. Stem Cell Rev. 2012;8:1188-98 pubmed publisher
Shipp C, Derhovanessian E, Pawelec G. Effect of culture at low oxygen tension on the expression of heat shock proteins in a panel of melanoma cell lines. PLoS ONE. 2012;7:e37475 pubmed publisher

product information

Product ID :

ADI-OSA-111PE

Catalog Number :

ADI-OSA-111PE-D

Product Name :

HO-1 monoclonal antibody (HO-1-2) (PE conjugate)

Host species :

Mouse

Clonality :

Monoclonal

Conjugation :

Product Type :

Antibody

Size :

50 µg

list of Pubmed id :

22983809, 22761656

Clone :

HO-1-2

Isotype :

IgG2b

SPECIES REACTIVITY :

Human, Mouse, Rat, Rabbit, Porcine, Monkey, Hamster, Guinea pig, Dog

Background :

Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

ALTnames :

HMOX1, Hsp32, Heat shock protein 32, Heme oxygenase 1

Immunogen :

Native rat HO-1.

Buffer :

Liquid. In PBS containing 0.09% sodium azide.

Application Summary :

Storage :

+4°C