HSP70/HSP72 (human), (recombinant) | Enzo Life Sciences ADI-NSP-555-D product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

HSP70/HSP72 (human), (recombinant)

catalog :

ADI-NSP-555-D

quantity :

50 µg

citations: 8

Reference
Teng Y, Rezvani K, De Biasi M. UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. Biochem Pharmacol. 2015;97:518-530 pubmed publisher
Tanaka T, Kajiwara T, Kutomi G, Kurotaki T, Saito K, Kanaseki T, et al. CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitating cross-presentation. Immunol Lett. 2015;167:34-40 pubmed publisher
Wang X, Zhou Y, Sun L, Chen W, Li X, Wang Q, et al. Complex formation between heat shock protein 72 and hepatitis B virus X protein in hepatocellular carcinoma tissues. J Proteome Res. 2008;7:5133-7 pubmed publisher
Futagami S, Hiratsuka T, Shindo T, Hamamoto T, Horie A, Ueki N, et al. Extracellular HSP70 blocks CD40L-induced apoptosis and tubular formation in endothelial cells. J Gastroenterol Hepatol. 2008;23 Suppl 2:S222-8 pubmed publisher
Quintana F, Farez M, Viglietta V, Iglesias A, Merbl Y, Izquierdo G, et al. Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc Natl Acad Sci U S A. 2008;105:18889-94 pubmed publisher
Zhu J, Quyyumi A, Wu H, Csako G, Rott D, Zalles Ganley A, et al. Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease. Arterioscler Thromb Vasc Biol. 2003;23:1055-9 pubmed
Pang Q, Christianson T, Keeble W, Koretsky T, Bagby G. The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC. J Biol Chem. 2002;277:49638-43 pubmed
Zhang X, Glendening C, Linke H, Parks C, Brooks C, Udem S, et al. Identification and characterization of a regulatory domain on the carboxyl terminus of the measles virus nucleocapsid protein. J Virol. 2002;76:8737-46 pubmed

product information

Product ID :

ADI-NSP-555

Catalog Number :

ADI-NSP-555-D

Product Name :

HSP70/HSP72 (human), (recombinant)

Product Type :

Protein

Size :

50 µg

list of Pubmed id :

26265139, 26141624, 19367718, 19120902, 19028871, 19028871, 12730089, 12397061, 12163594, 12163594

Background :

The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

ALTnames :

Heat shock protein 70, HspA1A, HspA1B

Purity :

≥95% (SDS-PAGE; Western blot)

Buffer :

Liquid. In Dulbecco's PBS.

Uses :

ATPase activity assay (positive). Western blot control.

Application Summary :

ELISA, IHC, WB, in vitro Assay, Apoptosis assay, Antigen microarray, Activity assay

Storage :

-80°C