p38 MAPK polyclonal antibody | Enzo Life Sciences ADI-KAS-MA009-E product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

p38 MAPK polyclonal antibody

catalog :

ADI-KAS-MA009-E

quantity :

100 µl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, chicken, bovine

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

Enzo Life Sciences product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; loading ...; fig 3	Bingula R, Dupuis C, Pichon C, Berthon J, Filaire M, Pigeon L, et al. Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 Cells In Vitro and In Vivo. J Oncol. 2016;2016:8162952 pubmed publisher

product information

Product ID :

ADI-KAS-MA009

Catalog Number :

ADI-KAS-MA009-E

Product Name :

p38 MAPK polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

100 µl

Image Legend 4 :

Western Blot analysis of p38 MAPK: Lane 1: MW Marker, Lane 2: HeLa, (Cell Lysate) (Prod. No. ADI-LYC-HL100), Lane 3: Brain (mouse), (tissue extract) (Prod. No. ADI-LYT-MB100), Lane 4: Brain (rat), (tissue extract) (Prod. No. ADI-LYT-RB100).

SPECIES REACTIVITY :

Human, Mouse, Rat, Sheep, Rabbit, Porcine, Monkey, Hamster, Guinea pig, Dog, Chicken, Bovine

Background :

Six proteins of the p38 subfamily of MAP kinases have been identified to date, including: p38alpha (SAPK2, CSBP) and its splice variant Mxi; p38beta and beta2; p38gamma (ERK6, SAPK3); and p38delta (SAPK4). p38 MAP kinases contain a conserved TGY motif in their activation loop and are activated in response to cytokines, hormones, GPCRs, and osmotic and heat shock to mediate primarily pro-apoptotic and pro-inflammatory responses. MKK3, MKK4, and MKK6 are known to activate p38 family members with varying specificity. All four p38 isoforms are able to phosphorylate the activating transcription factor 2 (ATF2), and differentially activate numerous substrates including Mnk1/2, Msk, phospholipase A2, and the MAPKAP kinase-2 and -3. Activated MAPKAP kinase-2 subsequently phosphorylates the heat shock protein Hsp27, an F-actin binding protein involved in cytoskeletal maintenance.

Immunogen :

Synthetic peptide corresponding to a portion of human p38. The sequence is completely conserved in mouse.

Buffer :

Liquid. Whole rabbit serum.

Uses :

Detects a band of ~43kDa by Western blot.

Application Summary :

IHC (PS), IP, WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage