Nrf2 polyclonal antibody | Enzo Life Sciences ADI-KAP-TF125-D product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Nrf2 polyclonal antibody

catalog :

ADI-KAP-TF125-D

quantity :

50 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs

application :

western blot

citations: 1

Reference
Xu Z, Sun Y, Guo Y, Qin G, Mu S, Fan R, et al. NF-YA promotes invasion and angiogenesis by upregulating EZH2-STAT3 signaling in human melanoma cells. Oncol Rep. 2016;35:3630-8 pubmed publisher

product information

Product ID :

ADI-KAP-TF125

Catalog Number :

ADI-KAP-TF125-D

Product Name :

Nrf2 polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

50 µg

list of Pubmed id :

26404472, 26176793, 25995631

SPECIES REACTIVITY :

Human, Mouse, Rat, Hamster, Guinea pig, Dog

Background :

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor, which regulates the expression of many detoxification and antioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar subfamily of basic leucine zipper (CNC-bZIP) transcription factors. The NF-E2 related family comprises of Nrf1 (TCFII), Nrf2, and Nrf3 and these proteins heterodimerize with Maf proteins to bind to Maf recognition element (MARE). Under normal conditions, Nrf2 is inactive and localized in the cytoplasm through its association with Keap1. When cells are exposed to electrophiles or oxidative stress generating agents cytoplasm localization of Nrf2 is inactivated and Nrf2 translocates into the nucleus and binds to specific DNA sequence elements known as NF-E2 binding site, Maf recognition element (MARE), stress response element or anti-oxidant response element (ARE). Studies have investigated the role of Nrf2 in urinary bladder carcinogenesis, pulmonary fibrosis, and smoke-induced emphysema. A study reported Nrf2-mediated ARE transcription to be a likely target of preventative therapy in neurodegenerative disorders such as Huntington's disease.

ALTnames :

Nuclear factor erythroid 2-related factor 2

Immunogen :

Synthetic peptide derived from the sequence of human Nrf2 (residues 40-60) with a cysteine residue added and coupled to KLH.

Buffer :

Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.

Application Summary :

Storage :

-20°C