[pSer1417]nNOS polyclonal antibody | Enzo Life Sciences ADI-KAP-NO032-D product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

[pSer1417]nNOS polyclonal antibody

catalog :

ADI-KAP-NO032-D

quantity :

50 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot

citations: 1

Reference
Tanaka S, Hosogi S, Sawabe Y, Shimamoto C, Matsumura H, Inui T, et al. PPAR? induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca(2+)-regulated exocytosis. Biomed Res. 2016;37:167-78 pubmed publisher

product information

Product ID :

ADI-KAP-NO032

Catalog Number :

ADI-KAP-NO032-D

Product Name :

[pSer1417]nNOS polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Antigen modification :

Phosphorylated

Product Type :

Antibody

Size :

50 µg

SPECIES REACTIVITY :

Human

Background :

The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.

ALTnames :

NOS1, Nitric oxide synthase (neuronal), NOS I

Immunogen :

Synthetic peptide corresponding to the sequence near the C-terminus of human nNOS phosphorylated at Ser1417.

Buffer :

Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.

Uses :

Detects a band of ~155kDa by Western blot.

Application Summary :

Storage :

-20°C