product summary
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company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
TIF1 β monoclonal antibody (20A1)
catalog :
ADI-KAM-TF200-F
quantity :
200 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
20A1
reactivity :
human
application :
western blot
more info or order :
citations: 1
product information
Product ID :
ADI-KAM-TF200
Catalog Number :
ADI-KAM-TF200-F
Product Name :
TIF1 β monoclonal antibody (20A1)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
200 µg
Clone :
20A1
Isotype :
IgG1
SPECIES REACTIVITY :
Human
Background :
Transcriptional intermediary factors (TIFs) are a group of transcriptional coactivators and corepressors that regulate gene expression by modulating chromatin structure and assembly of transcription initiation complexes. TIF1 beta (also known as KAP-1 or KRIP-1) is a member of the TIF1 subfamily of chromatin-associated TIFs that play a key role in many developmental and physiological processes. The three mammalian TIF1 proteins (TIF1 alpha, beta and gamma) share three conserved domains. An N-terminal RING-B box coiled coil (RBCC) domain most likely attributes to intermolecular structure, while two characteristic chromatin-targeting domains, a plextrin homology (PH) finger motif and bromodomain, are found in the C-terminus. TIF1 beta acts as a transcriptional repressor by modulating histone deacetlyation, histone H3 Ly-9 methylation, and recruitment of HP1 proteins. TIF1 beta was shown to form homo-oligomers in vitro, but does not form hetero-oligomers with TIF1 alpha or TIF1 gamma.
ALTnames :
Transcription intermediary factor 1β, E3 SUMO-protein ligase TRIM28
Immunogen :
Recombinant human TIF1β (N-terminal half).
Buffer :
Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Uses :
Detects a band of ~110kDa by Western blot.
Application Summary :
WB
Storage :
-20°C
more info or order :
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.