product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
DJ-1 monoclonal antibody (3E8)
catalog :
ADI-KAM-SA100-E
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3E8
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation, other
more info or order :
Enzo Life Sciences product webpage
citations: 4
Published Application/Species/Sample/DilutionReference
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human
Wang Z, Zhang Y, Zhang S, Guo Q, Tan Y, Wang X, et al. DJ-1 can inhibit microtubule associated protein 1 B formed aggregates. Mol Neurodegener. 2011;6:38 pubmed publisher
Rizzu P, Hinkle D, Zhukareva V, Bonifati V, Severijnen L, Martinez D, et al. DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia. Ann Neurol. 2004;55:113-8 pubmed
Le Naour F, Misek D, Krause M, Deneux L, Giordano T, Scholl S, et al. Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin Cancer Res. 2001;7:3328-35 pubmed
product information
Product ID :
ADI-KAM-SA100
Catalog Number :
ADI-KAM-SA100-E
Product Name :
DJ-1 monoclonal antibody (3E8)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
14705119, 11705844
Clone :
3E8
Isotype :
IgG1
SPECIES REACTIVITY :
Human
Background :
Researchers cloned DJ-1 protein, consisting of 189 amino acids, from a HeLa cell cDNA library as a oncogene which weakly transformed NIH3T3 cells. Cotransfection with ras or c-myc enhances transformation by DJ-11. DJ-1 expression is induced by growth signals, and it is translocated from the cytoplasm to the nucleus during the S phase without the presence of any nuclear localization signals. In addition to its potential involvement in ras-mediated signal transduction pathways, DJ-1 is known to regulate transcription of androgen-responsive genes, and is sensitive to oxidative stress. DJ-1 is ubiquitously expressed in various human tissues including the brain, with high expression in astrocytes of the frontal cortex and substantia nigra. Homozygous mutations in the DJ-1 gene have been shown to cause early-onset autosomal recessive Parkinson’s disease.
ALTnames :
PARK7, Parkinson disease protein 7
Immunogen :
Recombinant human DJ-1.
Buffer :
Liquid. In PBS, pH 7.2, containing 50% glycerol.
Uses :
Detects bands of ~28kDa by Western blot.
Application Summary :
WB
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.