This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
[pThr1342]DNA-topoisomerase II α monoclonal antibody (3D4)
catalog :
ADI-KAM-CC220-E
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
3D4
reactivity :
human
application :
western blot, immunocytochemistry
product information
Product ID :
ADI-KAM-CC220
Catalog Number :
ADI-KAM-CC220-E
Product Name :
[pThr1342]DNA-topoisomerase II α monoclonal antibody (3D4)
Host species :
Mouse
Clonality :
Monoclonal
Antigen modification :
Phosphorylated
Product Type :
Antibody
Size :
100 µg
Clone :
3D4
Isotype :
IgG1
SPECIES REACTIVITY :
Human
Background :
DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.
Immunogen :
Synthetic peptide corresponding to a portion of human Topoisomerase IIα phosphorylated at Tyr1342.
Buffer :
Liquid. In PBS, pH 7.2, containing 50% glycerol.
Uses :
Detects a band of ~170kDa by Western blot.
Application Summary :
ICC, WB
Storage :
-20°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.