CENP-A monoclonal antibody (3-19) | Enzo Life Sciences ADI-KAM-CC006-E product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

CENP-A monoclonal antibody (3-19)

catalog :

ADI-KAM-CC006-E

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3-19

The same clone is also sold as:

Invitrogen: MA1-20832

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, other

more info or order :

Enzo Life Sciences product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 1e	Logsdon G, Gambogi C, Liskovykh M, Barrey E, Larionov V, Miga K, et al. Human Artificial Chromosomes that Bypass Centromeric DNA. Cell. 2019;178:624-639.e19 pubmed publisher
immunocytochemistry; human; loading ...; fig 7a	Gentili M, Lahaye X, Nadalin F, Nader G, Puig Lombardi E, Hervé S, et al. The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus. Cell Rep. 2019;26:2377-2393.e13 pubmed publisher
other; human; loading ...; fig st1	Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
immunocytochemistry; human; fig 1	Logsdon G, Barrey E, Bassett E, Denizio J, Guo L, Panchenko T, et al. Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. J Cell Biol. 2015;208:521-31 pubmed publisher
	Hayden K, Willard H. Composition and organization of active centromere sequences in complex genomes. BMC Genomics. 2012;13:324 pubmed publisher

product information

Product ID :

ADI-KAM-CC006

Catalog Number :

ADI-KAM-CC006-E

Product Name :

CENP-A monoclonal antibody (3-19)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µg

list of Pubmed id :

22817545

Clone :

3-19

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

Centromere protein A (CENP-A), a 17-19 kDa centromere-specific histone variant, is 62% identical to the carboxy-terminal domain of histone H3. In the presence of DNA, CENP-A forms an octameric complex with histones H4, H2A, and H2B. CENP-A defines active centromere regions by forming centromere-specific nucleosomes on which kinetochores are assembled. CENP-A resides specifically in the inner plate of the kinetochore, and is essential for kinetochore targeting of CENP-C and other kinetochore components. CENP-A is required for nucleosomal packaging of centromeric DNA at interphase.

ALTnames :

Centromere protein A

Immunogen :

Synthetic peptide corresponding to a portion of human CENP-A .

Buffer :

Liquid. In PBS, pH 7.2, containing 50% glycerol.

Uses :

Detects bands of ~18kDa by Western blot.

Application Summary :

ICC, IHC, WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage