HSP90α (human), ELISA kit | Enzo Life Sciences ADI-EKS-895 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

HSP90α (human), ELISA kit

catalog :

ADI-EKS-895

quantity :

96 wells

citations: 5

Reference
Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval J, et al. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun. 2018;9:1431 pubmed publisher
Shervington L, Patil H, Shervington A. Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment. J Cancer. 2015;6:786-94 pubmed publisher
Ersvaer E, Brenner A, VetÃ¥s K, Reikvam H, Bruserud Ã. Effects of cytarabine on activation of human T cells - cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid. BMC Pharmacol Toxicol. 2015;16:12 pubmed publisher
Musiał K, Zwolinska D. Novel indicators of fibrosis-related complications in children with chronic kidney disease. Clin Chim Acta. 2014;430:15-9 pubmed publisher
Hance M, Dole K, Gopal U, Bohonowych J, Jezierska Drutel A, Neumann C, et al. Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer. J Biol Chem. 2012;287:37732-44 pubmed publisher

product information

Product ID :

ADI-EKS-895

Catalog Number :

ADI-EKS-895

Product Name :

HSP90α (human), ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

26185541, 25934555, 22989880

Product Description :

The HSP90α (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in < 3 hours. Absorbance is read at 450 nm. Save time, money, and precious sample with fully quantitative results and increased sensitivity compared to Western blot analysis.

SPECIES REACTIVITY :

Human

Background :

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

ALTnames :

Heat shock protein 90α, HSP86

Uses :

For the quantitative determination of HSP90α in cell lysates, serum, and tissue of human origin.

Application Summary :

ELISA, Colorimetric detection