CLIP monoclonal antibody (CerCLIP.1) | Enzo Life Sciences ADI-CSA-600-F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

CLIP monoclonal antibody (CerCLIP.1)

catalog :

ADI-CSA-600-F

quantity :

200 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CerCLIP.1

application :

immunoprecipitation, flow cytometry

citations: 3

Reference
Denzin L, Hammond C, Cresswell P. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J Exp Med. 1996;184:2153-65 pubmed
Denzin L, Cresswell P. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell. 1995;82:155-65 pubmed
Denzin L, Robbins N, Carboy Newcomb C, Cresswell P. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity. 1994;1:595-606 pubmed

product information

Product ID :

ADI-CSA-600

Catalog Number :

ADI-CSA-600-F

Product Name :

CLIP monoclonal antibody (CerCLIP.1)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

200 µg

list of Pubmed id :

8976171, 7606781, 7600288

Clone :

CerCLIP.1

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

CLIP (class II-associated invariant chain peptide) is an important peptide in the MHC-II antigen processing pathway, formed by the enzymatic cleavage of amino acids 81-104 from the invariant chain. During MHC-II synthesis in the ER and transport to endocytic vesicles, the antigen binding site of MHC-II is obstructed by the presence of the invariant chain. As the MHC-II complex moves through the Golgi, the invariant chain is degraded, leaving the CLIP fragment in the MHC-II peptide binding groove. CLIP is eventually displaced by the loading of antigenic peptides, followed by presentation on the APC cell surface to CD4+ T-cells.

Immunogen :

Synthetic peptide corresponding to a portion of human CLIP.

Buffer :

Liquid. In PBS containing 0.09% sodium azide.

Application Summary :

FC, IP

Storage :

-20°C