BAG-1M (human), (recombinant) (His-tag) | Enzo Life Sciences ADI-APR-400-0200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

BAG-1M (human), (recombinant) (His-tag)

catalog :

ADI-APR-400-0200

quantity :

200 µg

product information

Product ID :

ADI-APR-400

Catalog Number :

ADI-APR-400-0200

Product Name :

BAG-1M (human), (recombinant) (His-tag)

Product Type :

Protein

Size :

200 µg

Background :

BAG-1 is a Bcl-2-binding protein which lacks sequence homology with Bcl-2 and its related proteins, and functions to enhance the anti-apoptotic effects of Bcl- 2. BAG-1 is expressed as three major functionally distinct and differentially localized isoforms, which originate from a single mRNA. BAG-1S, 36 kDa, typically found in cytoplasm, generally the most abundant isoform in normal cells; BAG-1M, 46 kDa, found in both the nucleus and cytoplasm and under certain conditions, it can translocate from cytoplasm to nucleus; and BAG-1L, 50 kDa, nuclear localized, involved in regulating transcription. BAG-1 binds to the intracellular domain of the hepatocyte growth factor (HGF) and platelet-derived growth factor (PDGF) receptors, enhancing growth factor mediated protection from apoptosis. BAG-1 binds to the ATPase domain of Hsc70/Hsp70 to modulate its chaperone activity, in-part regulating Raf-1 activity and the assembly of glucocorticoid receptors.

ALTnames :

BCL2-associated athanogene

Purity :

≥80% (SDS-PAGE; Western Blot)

Buffer :

Liquid. In 20mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 1mM DTT, and 1% glycerol.

Uses :

Western blot control.

Application Summary :

Storage :

-80°C