product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
TRAIL-R4 polyclonal antibody
catalog :
ADI-AAP-371-E
quantity :
100 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Enzo Life Sciences product webpage
citations: 3
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 1g
Gal H, Lysenko M, Stroganov S, Vadai E, Youssef S, Tzadikevitch Geffen K, et al. Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019;38:e100849 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4e
Lesina M, Wörmann S, Morton J, Diakopoulos K, Korneeva O, Wimmer M, et al. RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. J Clin Invest. 2016;126:2919-32 pubmed publisher
Wiel C, Gras B, Vindrieux D, Warnier M, Gitenay D, Le Calvé B, et al. Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape. Oncogene. 2016;35:1596-601 pubmed publisher
product information
Product ID :
ADI-AAP-371
Catalog Number :
ADI-AAP-371-E
Product Name :
TRAIL-R4 polyclonal antibody
Host species :
Rabbit
Clonality :
Polyclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
26073088, 12021051
SPECIES REACTIVITY :
Human, Mouse, Rat
Background :
Decoy receptors (DcRs) are signaling-deficient receptors for certain members of the TNF family of cytokines, including TRAIL/Apo2L and FasL. Functional TRAIL receptors such as DR4 and DR5 transmit apoptotic signals via their intracellular death domains. In contrast, three identified TRAIL decoy receptors (DcR1, DcR2, and osteoprotegerin/OPG) completely or partially lack the signaling death domain, and/or are secreted from cells and unable to transmit intracellular signals. Thus, expression of DcRs promotes survival by sequestration of apoptotic ligands. A fourth identified decoy receptor, DcR3, binds both FasL and the vascular endothelial cell growth inhibitor (VEGI), inhibiting Fas and DR3 death signals.
ALTnames :
TRAIL receptor 4, DcR2, Death Receptor 2, TRUNDD, CD264, TNFRSF 10D, TNFRSF 10D, TNF-related apoptosis-inducing ligand receptor 4, Tumor necrosis factor receptor superfamily member 10D
Immunogen :
Synthetic peptide corresponding to a portion of human TRAIL-R4.
Buffer :
Liquid. In PBS containing 0.02% sodium azide.
Uses :
Detects a band of ~36kDa by Western blot.
Application Summary :
ICC, IHC, WB
Storage :
+4°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.